Department of Physiology and Biophysics
Dr. Melanie Matheu is the founder of Prellis Biologics. Dr. Matheu studied immunology for 15 years and authored numerous peer-reviewed publications and a book chapter detailing methods and approaches for high-resolution imaging in tissues before starting Prellis Biologics in October 2016. She was inspired to find a way to reverse-engineer laser-based imaging systems into a printer when she realized that the final roadblock in engineering human tissue and organs for transplant was a simple and well-defined engineering problem: how can microvasculature be printed fast enough to build human tissues? Prellis Biologics' technology solves this problem by partially decoupling printing speed from resolution with a novel patent-pending laser based projection system.
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses.
Nature immunology Dec, 2005 | Pubmed ID: 16273098
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.
Nature chemical biology Aug, 2006 | Pubmed ID: 16829954
Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2007 | Pubmed ID: 17675487
Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block.
Immunity Oct, 2008 | Pubmed ID: 18835197
General approach to adoptive transfer and cell labeling for immunoimaging.
Cold Spring Harbor protocols Jan, 2011 | Pubmed ID: 21285265
Induction of an immune response for imaging antigen-presenting cell/T-cell interactions.
Cold Spring Harbor protocols Jan, 2011 | Pubmed ID: 21285266
In situ lymph node imaging.
Cold Spring Harbor protocols Jan, 2011 | Pubmed ID: 21285267
In vivo lymph node imaging.
Cold Spring Harbor protocols Jan, 2011 | Pubmed ID: 21285268
Immunoimaging: studying immune system dynamics using two-photon microscopy.
Cold Spring Harbor protocols Jan, 2011 | Pubmed ID: 21285279
Jason G. Weinger1,
Milton L. Greenberg2,
Melanie P. Matheu4,
Ian Parker3,
Craig M. Walsh1,
Thomas E. Lane5,
Michael D. Cahalan2
1Molecular Biology and Biochemistry, University of California, Irvine,
2Physiology and Biophysics, University of California, Irvine,
3Neurobiology and Behavior, University of California, Irvine,
4University of California San Francisco Diabetes Center, University of California, San Francisco,
5Pathology, University of Utah
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