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Department of Nuclear Medicine and Radiobiology,
Sherbrooke Molecular Imaging Center (CIMS)
Jeffrey V. Leyton has not added Biography.
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The human polynucleotide kinase/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 ¹¹¹In-NLS-7G3 radioimmunoconjugates.
Nuclear medicine and biology May-Jun, 2014 | Pubmed ID: 24637100
Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute myeloid leukemia (AML) cells displaying the CD123(+)/CD131(-) phenotype of leukemia stem cells.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Apr, 2016 | Pubmed ID: 26748017
ChAcNLS, a Novel Modification to Antibody-Conjugates Permitting Target Cell-Specific Endosomal Escape, Localization to the Nucleus, and Enhanced Total Intracellular Accumulation.
Molecular pharmaceutics Jun, 2016 | Pubmed ID: 27112376
Development of a Novel Covalent Folate-Albumin-Photosensitizer Conjugate.
Photochemistry and photobiology 07, 2016 | Pubmed ID: 27221219
Paradoxical effects of Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates on hCD45(+) cells in the bone marrow and spleen of leukemia-engrafted NOD/SCID or NRG mice.
Nuclear medicine and biology Oct, 2016 | Pubmed ID: 27497632
BODIPY-17α-ethynylestradiol conjugates: Synthesis, fluorescence properties and receptor binding affinities.
Bioorganic & medicinal chemistry letters Feb, 2017 | Pubmed ID: 28049591
Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer.
Oncoimmunology , 2017 | Pubmed ID: 29123949
Université de Sherbrooke
Sherbrooke Institute of Pharmacology
Simon Beaudoin1,
Michel Paquette1,
Laurent Fafard-Couture1,
Mylene A. Tremblay1,
Roger Lecomte1,2,3,
Brigitte Guérin1,2,3,
Jeffrey V. Leyton1,2,3
1Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke,
2Sherbrooke Molecular Imaging Center (CIMS), Université de Sherbrooke,
3, Sherbrooke Institute of Pharmacology
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