Department of Clinical Research,
Department for Biomedical Research
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Successful management of an ABO-mismatched lung allograft using antigen-specific immunoadsorption, complement inhibition, and immunomodulatory therapy.
Transplantation Jul, 2002 | Pubmed ID: 12134103
C1-inhibitor in patients with severe sepsis and septic shock: beneficial effect on renal dysfunction.
Critical care medicine Aug, 2002 | Pubmed ID: 12163783
Activation of complement pathways in xenotransplantation: an in vitro study.
Transplant immunology May, 2002 | Pubmed ID: 12180841
P-selectin blocking potency of multimeric tyrosine sulfates in vitro and in vivo.
Bioorganic & medicinal chemistry letters May, 2003 | Pubmed ID: 12729647
Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells.
Transplantation Sep, 2003 | Pubmed ID: 14501864
IgM-enriched human introvenous immunoglobulin strongly inhibits complement-dependent porcine cell cytotoxicity mediated by human xenoreactive antibodies.
Xenotransplantation Nov, 2003 | Pubmed ID: 14708528
Immunoglobulin M-enriched intravenous immunoglobulin inhibits classical pathway complement activation, but not bactericidal activity of human serum.
Xenotransplantation Mar, 2004 | Pubmed ID: 14962276
Endothelial cell protection by dextran sulfate: a novel strategy to prevent acute vascular rejection in xenotransplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Feb, 2004 | Pubmed ID: 14974938
Multimeric tyrosine sulfate acts as an endothelial cell protectant and prevents complement activation in xenotransplantation models.
Xenotransplantation May, 2004 | Pubmed ID: 15099206
Lack of galactose-alpha-1,3-galactose expression on porcine endothelial cells prevents complement-induced lysis but not direct xenogeneic NK cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) May, 2004 | Pubmed ID: 15128838
Xenograft rejection: IgG1, complement and NK cells team up to activate and destroy the endothelium.
Trends in immunology Jan, 2005 | Pubmed ID: 15629401
Histo-blood group antigens as allo- and autoantigens.
Annals of the New York Academy of Sciences Jun, 2005 | Pubmed ID: 16014519
Locally targeted cytoprotection with dextran sulfate attenuates experimental porcine myocardial ischaemia/reperfusion injury.
European heart journal Nov, 2005 | Pubmed ID: 16055495
Endothelial cell protection and complement inhibition in xenotransplantation: a novel in vitro model using whole blood.
Xenotransplantation Nov, 2005 | Pubmed ID: 16202066
Endothelial cell protection in xenotransplantation: looking after a key player in rejection.
Xenotransplantation Jan, 2006 | Pubmed ID: 16497209
Reactivity of human natural antibodies to endothelial cells from Galalpha(1,3)Gal-deficient pigs.
Transplantation Jan, 2007 | Pubmed ID: 17264816
AB0 blood group incompatible haematopoietic stem cell transplantation and xenograft rejection.
Swiss medical weekly Jan, 2007 | Pubmed ID: 17299663
Attenuation of myocardial reperfusion injury in pigs by Mirococept, a membrane-targeted complement inhibitor derived from human CR1.
Cardiovascular research Dec, 2007 | Pubmed ID: 17825275
ABO blood group incompatible haematopoietic stem cell transplantation and xenograft rejection.
Swiss medical weekly Mar, 2007 | Pubmed ID: 17874513
Normal human serum contains high levels of anti-Gal alpha 1-4GlcNAc antibodies.
Xenotransplantation Nov, 2007 | Pubmed ID: 17991151
Addition of dextran sulfate to blood cardioplegia attenuates reperfusion injury in a porcine model of cardiopulmonary bypass.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Sep, 2008 | Pubmed ID: 18572413
The complement inhibitor low molecular weight dextran sulfate prevents TLR4-induced phenotypic and functional maturation of human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2008 | Pubmed ID: 18606639
Low molecular weight dextran sulfate as complement inhibitor and cytoprotectant in solid organ and islet transplantation.
Molecular immunology Oct, 2008 | Pubmed ID: 18722664
TLR2 and TLR4 agonists induce production of the vasoactive peptide endothelin-1 by human dendritic cells.
Molecular immunology Sep, 2009 | Pubmed ID: 19559483
Dextran sulfate modulates MAP kinase signaling and reduces endothelial injury in a rat aortic clamping model.
Journal of vascular surgery Jul, 2009 | Pubmed ID: 19563964
Exploring natural anticoagulation by endothelial cells: a novel in vitro model.
ALTEX , 2007 | Pubmed ID: 19835045
Preservation of amputated extremities by extracorporeal blood perfusion; a feasibility study in a porcine model.
The Journal of surgical research Nov, 2011 | Pubmed ID: 20451920
Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions.
PloS one , 2010 | Pubmed ID: 20539755
Inhibition of direct and indirect TLR-mediated activation of human NK cells by low molecular weight dextran sulfate.
Molecular immunology Aug, 2010 | Pubmed ID: 20541808
Multiplex suspension array for human anti-carbohydrate antibody profiling.
The Analyst Feb, 2011 | Pubmed ID: 21107457
Role of complement and perspectives for intervention in ischemia-reperfusion damage.
Annals of medicine May, 2012 | Pubmed ID: 21254897
Autotransfusion system or integrated automatic suction device in minimized extracorporeal circulation: influence on coagulation and inflammatory response.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery May, 2011 | Pubmed ID: 21334912
Evaluation of multimeric tyrosine-O-sulfate as a cytoprotectant in an in vivo model of acute myocardial infarction in pigs.
Cardiology , 2012 | Pubmed ID: 22398380
Pancuronium dose refinement in experimental pigs used in cardiovascular research.
Veterinary anaesthesia and analgesia Sep, 2012 | Pubmed ID: 22486886
Assessment of endothelium and inflammatory response at the onset of reperfusion injury in hand surgery.
Journal of inflammation (London, England) May, 2012 | Pubmed ID: 22583529
Ischemia/reperfusion injury of porcine limbs after extracorporeal perfusion.
The Journal of surgical research May, 2013 | Pubmed ID: 22748598
Microsurgery and liver research: Lumbricus terrestris, a reliable animal model for training?
Clinics and research in hepatology and gastroenterology Apr, 2013 | Pubmed ID: 22795317
Development of a bead-based multiplex assay for the simultaneous detection of porcine inflammation markers using xMAP technology.
Cytometry. Part A : the journal of the International Society for Analytical Cytology Jul, 2013 | Pubmed ID: 23576245
Botulinum toxin A and B raise blood flow and increase survival of critically ischemic skin flaps.
The Journal of surgical research Oct, 2013 | Pubmed ID: 23651811
Combined inhibition of complement C5 and CD14 markedly attenuates inflammation, thrombogenicity, and hemodynamic changes in porcine sepsis.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2013 | Pubmed ID: 23761634
Edema is a sign of early acute myocardial infarction on post-mortem magnetic resonance imaging.
Forensic science, medicine, and pathology Dec, 2013 | Pubmed ID: 23783421
Effect of pressure-controlled intermittent coronary sinus occlusion (PICSO) on myocardial ischaemia and reperfusion in a closed-chest porcine model.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology Jul, 2013 | Pubmed ID: 23872654
Activation of the lectin pathway of complement in pig-to-human xenotransplantation models.
Transplantation Nov, 2013 | Pubmed ID: 23958924
Reconstituted high-density lipoprotein modulates activation of human leukocytes.
PloS one , 2013 | Pubmed ID: 23967171
C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage.
PloS one , 2013 | Pubmed ID: 23991040
Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs.
Transplantation Jan, 2014 | Pubmed ID: 24150517
Use of dextran sulfate in tourniquet-induced skeletal muscle reperfusion injury.
The Journal of surgical research Mar, 2014 | Pubmed ID: 24176204
Ischemia/reperfusion injury: effect of simultaneous inhibition of plasma cascade systems versus specific complement inhibition.
Biochemical pharmacology Mar, 2014 | Pubmed ID: 24384116
Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood.
Xenotransplantation May-Jun, 2014 | Pubmed ID: 24635052
A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft.
Science translational medicine Aug, 2014 | Pubmed ID: 25122638
Porcine extrahepatic vascular endothelial asialoglycoprotein receptor 1 mediates xenogeneic platelet phagocytosis in vitro and in human-to-pig ex vivo xenoperfusion.
Transplantation Apr, 2015 | Pubmed ID: 25675194
Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14.
Immunobiology Aug, 2015 | Pubmed ID: 25956456
Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions.
Transplantation Oct, 2015 | Pubmed ID: 25965410
Endothelial- and Platelet-Derived Microparticles Are Generated During Liver Resection in Humans.
Journal of investigative surgery : the official journal of the Academy of Surgical Research , 2016 | Pubmed ID: 26375814
Modifying the Glycome in Pigs for Xenotransplantation.
Transplantation Mar, 2016 | Pubmed ID: 26906937
Higher macrophage superoxide anion production in coronary artery disease (CAD) patients with Type D personality.
Psychoneuroendocrinology Jun, 2016 | Pubmed ID: 26994482
Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation.
Transplantation Sep, 2016 | Pubmed ID: 27077599
Correlation Between Sonographic and In Vivo Measurement of A1 Pulleys in Trigger Fingers.
Ultrasound in medicine & biology Jul, 2016 | Pubmed ID: 27126241
Vitreal Cytokine Profile Differences Between Eyes With Epiretinal Membranes or Macular Holes.
Investigative ophthalmology & visual science Nov, 2016 | Pubmed ID: 27893098
Dexrazoxane Shows No Protective Effect in the Acute Phase of Reperfusion during Myocardial Infarction in Pigs.
PloS one , 2016 | Pubmed ID: 28002439
Role of the plasma cascade systems in ischemia/reperfusion injury of bone.
Bone Apr, 2017 | Pubmed ID: 28159709
Xenotransplantation: Where do we stand in 2016?
Swiss medical weekly Mar, 2017 | Pubmed ID: 28322428
Effect of C1-INH on ischemia/reperfusion injury in a porcine limb ex vivo perfusion model.
Molecular immunology Aug, 2017 | Pubmed ID: 28641140
Surface modification of pig endothelial cells with a branched heparin conjugate improves their compatibility with human blood.
Scientific reports Jun, 2017 | Pubmed ID: 28667310
Bioengineering a Human Face Graft: The Matrix of Identity.
Annals of surgery Jul, 2017 | Pubmed ID: 28742686
Intra-graft injection of tacrolimus promotes survival of vascularized composite allotransplantation.
The Journal of surgical research Oct, 2017 | Pubmed ID: 28985877
Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood.
Xenotransplantation Jan, 2018 | Pubmed ID: 29057510
Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia-reperfusion injury model.
Journal of vascular surgery Jan, 2018 | Pubmed ID: 29395422
Type II Minimal-Invasive Extracorporeal Circuit for Aortic Valve Replacement: A Randomized Controlled Trial.
Artificial organs Feb, 2018 | Pubmed ID: 29435996
1Department of Clinical Research, University of Bern,
2Graduate School for Cellular and Biomedical Sciences, University of Bern,
3Immunology Research Centre, St. Vincent's Hospital Melbourne,
4Institute of Pathology, University of Bern,
5Institute of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilian University
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