Jianjie Ma

Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals.

Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.

Stimulatory and Inhibitory Functions of the R Domain on CFTR Chloride Channel.

The transmembrane segment of ryanodine receptor contains an intracellular membrane retention signal for Ca(2+) release channel.

A short segment of the R domain of cystic fibrosis transmembrane conductance regulator contains channel stimulatory and inhibitory activities that are separable by sequence modification.

Dysfunction of store-operated calcium channel in muscle cells lacking mg29.

Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor.

Ca(2+)-dependent interaction between FKBP12 and calcineurin regulates activity of the Ca(2+) release channel in skeletal muscle.

A retrograde signal from calsequestrin for the regulation of store-operated Ca2+ entry in skeletal muscle.

Junctional membrane structure and store operated calcium entry in muscle cells.

Targeting of protein kinase A by muscle A kinase-anchoring protein (mAKAP) regulates phosphorylation and function of the skeletal muscle ryanodine receptor.

Retrograde activation of store-operated calcium channel.

Intermolecular interaction between R domains of cystic fibrosis transmembrane conductance regulator.

Negatively charged amino acids within the intraluminal loop of ryanodine receptor are involved in the interaction with triadin.

Co-expression of MG29 and ryanodine receptor leads to apoptotic cell death: effect mediated by intracellular Ca2+ release.

Membrane topology and membrane retention of the ryanodine receptor calcium release channel.

Nuclear translocation of cytochrome c during apoptosis.

The role of glycine residues in the function of human organic anion transporter 4.

Calcium-dependent facilitation and graded deactivation of store-operated calcium entry in fetal skeletal muscle.

Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4).

The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4.

Probing a putative dantrolene-binding site on the cardiac ryanodine receptor.

A rapid and efficient PCR-based mutagenesis method applicable to cell physiology study.

Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle.

Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice.

Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea.

Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes.

The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis.

Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells.

Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.

Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release.

Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor.

Determination of the external loops and the cellular orientation of the N- and the C-termini of the human organic anion transporter hOAT1.

Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.

Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle.

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans.

TRIC channels are essential for Ca2+ handling in intracellular stores.

The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis.

Immuno-proteomic approach to excitation--contraction coupling in skeletal and cardiac muscle: molecular insights revealed by the mitsugumins.

Overexpression of Bax induces down-regulation of store-operated calcium entry in prostate cancer cells.

Altered Ca2+ sparks in aging skeletal and cardiac muscle.

Compromised store-operated Ca2+ entry in aged skeletal muscle.

Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells.

Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway.

Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.

MG53 regulates membrane budding and exocytosis in muscle cells.

MG53 nucleates assembly of cell membrane repair machinery.

The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells.

Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes.

Glutamate at position 227 of junctophilin-2 is involved in binding to TRPC3.

Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin.

NAADP mobilizes calcium from acidic organelles through two-pore channels.

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.

Mitsugumin 53 (MG53) facilitates vesicle trafficking in striated muscle to contribute to cell membrane repair.

Calcium signaling via two-pore channels: local or global, that is the question.

Impaired interaction between skeletal ryanodine receptors in malignant hyperthermia.

S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle.

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP.

Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair.

2-Methoxyoestradiol inhibits glucose transport in rodent skeletal muscle.

MG53 constitutes a primary determinant of cardiac ischemic preconditioning.

Two-pore channels for integrative Ca signaling.

Bid agonist regulates murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis.

Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel.

Increased store-operated Ca2+ entry in skeletal muscle with reduced calsequestrin-1 expression.

Ca2+ overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle.

Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes.

An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell.

Amphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanisms.

Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.

Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels.

MG53 participates in ischaemic postconditioning through the RISK signalling pathway.

Polymerase transcriptase release factor (PTRF) anchors MG53 protein to cell injury site for initiation of membrane repair.

Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch.

tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1.

Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway.

A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice.

Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair.

Molecular architecture of Ca2+ signaling control in muscle and heart cells.

Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling.

Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1.

Detection of calcium sparks in intact and permeabilized skeletal muscle fibers.

Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair.

Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in δ-Sarcoglycan-deficient Hamsters.

Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1.

Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy.

Switch from ER-mitochondrial to SR-mitochondrial calcium coupling during muscle differentiation.

TRIM50 Protein Regulates Vesicular Trafficking for Acid Secretion in Gastric Parietal Cells.

Mitsugumin 53 attenuates the activity of sarcoplasmic reticulum Ca(2+)-ATPase 1a (SERCA1a) in skeletal muscle.

The Mesobuthus martensii genome reveals the molecular diversity of scorpion toxins.

The effect of recombinant human MG53 protein on tourniquet-induced ischemia reperfusion injury in rat muscle.

Store-operated Ca2+ entry in muscle physiology and diseases.

Trimeric intracellular cation channels and sarcoplasmic/endoplasmic reticulum calcium homeostasis.

Core-shell nanoparticle-based peptide therapeutics and combined hyperthermia for enhanced cancer cell apoptosis.

Amphipathic tail-anchoring peptide is a promising therapeutic agent for prostate cancer treatment.

Cell membrane damage is involved in the impaired survival of bone marrow stem cells by oxidized low-density lipoprotein.

Organelle-specific subunit interactions of the vertebrate two-pore channel family.

Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.

Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy.

Cardioprotection of recombinant human MG53 protein in a porcine model of ischemia and reperfusion injury.

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia.

Amelioration of ischemia-reperfusion-induced muscle injury by the recombinant human MG53 protein.

3D multifocus astigmatism and compressed sensing (3D MACS) based superresolution reconstruction.

Zinc Binding to MG53 Protein Facilitates Repair of Injury to Cell Membranes.

Modulation of wound healing and scar formation by MG53 protein-mediated cell membrane repair.

CRISPR-mediated Genome Editing Restores Dystrophin Expression and Function in mdx Mice.

Quantifying Drug-Induced Nanomechanics and Mechanical Effects to Single Cardiomyocytes for Optimal Drug Administration To Minimize Cardiotoxicity.

Autophagy, Innate Immunity and Tissue Repair in Acute Kidney Injury.

Dual function of MG53 in membrane repair and insulin signaling.

Absence of physiological Ca transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation.

In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury.

Zinc in Wound Healing Modulation.

Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster.

Quantum confined peptide assemblies with tunable visible to near-infrared spectral range.

MG 53 Protein Protects Aortic Valve Interstitial Cells From Membrane Injury and Fibrocalcific Remodeling.

MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents.

MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-κB pathway in vitro and in vivo.

Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function.

N-acetylcysteine prevents oxidized low-density lipoprotein-induced reduction of MG53 and enhances MG53 protective effect on bone marrow stem cells.

The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury.

TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle.

MG53 Does Not Manifest the Development of Diabetes in Mice.

MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling.

Peptidylarginine Deiminases 2 Mediates Caspase-1-Associated Lethality in Pseudomonas aeruginosa Pneumonia-Induced Sepsis.

Recombinant MG53 Protein Protects Mice from Lethal Influenza Virus Infection.

MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine.

TRIC-A regulates intracellular Ca homeostasis in cardiomyocytes.

MG53 as a Novel Therapeutic Protein to Treat Acute Lung Injury.

Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration.

Efficient precise in vivo base editing in adult dystrophic mice.

MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.

Correction to: The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury.