Department of Urology,
Center for Immunology,
Microbiology,
Immunology,
and Cancer Biology Graduate Program,
Masonic Cancer Center,
Microbiology, Immunology, and Cancer Biology Graduate Program
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Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2002 | Pubmed ID: 12023355
Induction and regulation of tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand-mediated apoptosis in renal cell carcinoma.
Cancer research Jun, 2002 | Pubmed ID: 12036919
TRAIL: a mechanism of tumor surveillance in an immune privileged site.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2002 | Pubmed ID: 12391182
Cell death and immune privilege.
International reviews of immunology Mar-Jun, 2002 | Pubmed ID: 12424841
Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligand.
Cancer research Dec, 2002 | Pubmed ID: 12499252
Apoptosis, tolerance, and regulatory T cells--old wine, new wineskins.
Immunological reviews Jun, 2003 | Pubmed ID: 12752676
The topoisomerase I inhibitor topotecan increases the sensitivity of prostate tumor cells to TRAIL/Apo-2L-induced apoptosis.
Cancer chemotherapy and pharmacology Sep, 2003 | Pubmed ID: 12811515
Plasmacytoid dendritic cell-derived IFN-alpha induces TNF-related apoptosis-inducing ligand/Apo-2L-mediated antitumor activity by human monocytes following CpG oligodeoxynucleotide stimulation.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2003 | Pubmed ID: 12817000
Structure/function analysis of the murine CD95L promoter reveals the identification of a novel transcriptional repressor and functional CD28 response element.
The Journal of biological chemistry Sep, 2003 | Pubmed ID: 12855690
Tumor necrosis factor-related apoptosis-inducing ligand: a novel mechanism for Bacillus Calmette-Guérin-induced antitumor activity.
Cancer research May, 2004 | Pubmed ID: 15150089
Human B cells express functional TRAIL/Apo-2 ligand after CpG-containing oligodeoxynucleotide stimulation.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2004 | Pubmed ID: 15240676
Inhibition of the NF-kappaB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cells.
Cancer gene therapy Oct, 2004 | Pubmed ID: 15332116
Expression of TNF-related apoptosis-inducing ligand (TRAIL) in megakaryocytes and platelets.
Experimental hematology Nov, 2004 | Pubmed ID: 15539085
Immunostimulatory oligodeoxynucleotides induce apoptosis of B cell chronic lymphocytic leukemia cells.
Journal of leukocyte biology Mar, 2005 | Pubmed ID: 15582984
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.
Nature Mar, 2005 | Pubmed ID: 15744305
Depsipeptide (FR901228) enhances the cytotoxic activity of TRAIL by redistributing TRAIL receptor to membrane lipid rafts.
Molecular therapy : the journal of the American Society of Gene Therapy Apr, 2005 | Pubmed ID: 15771957
Neutrophil stimulation with Mycobacterium bovis bacillus Calmette-Guerin (BCG) results in the release of functional soluble TRAIL/Apo-2L.
Blood Nov, 2005 | Pubmed ID: 16037389
Histone deacetylase inhibitors modulate renal cell carcinoma sensitivity to TRAIL/Apo-2L-induced apoptosis by enhancing TRAIL-R2 expression.
Cancer biology & therapy Oct, 2005 | Pubmed ID: 16096370
Histone deacetylase inhibitors modulate the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand-resistant bladder tumor cells.
Cancer research Jan, 2006 | Pubmed ID: 16397266
Neisseria gonorrhoeae delays the onset of apoptosis in polymorphonuclear leukocytes.
Cellular microbiology Nov, 2006 | Pubmed ID: 16803582
TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2006 | Pubmed ID: 16818756
Survivin inhibits apoptosis induced by TRAIL, and the ratio between survivin and TRAIL receptors is predictive of recurrent disease in neuroblastoma.
Journal of pediatric surgery Aug, 2006 | Pubmed ID: 16863850
A vision of cell death: Fas ligand and immune privilege 10 years later.
Immunological reviews Oct, 2006 | Pubmed ID: 16972907
Induction of protective immunity to RM-1 prostate cancer cells with ALVAC-IL-2/IL-12/TNF-alpha combination therapy.
International journal of cancer Dec, 2006 | Pubmed ID: 16991124
Identification of the mycobacterial subcomponents involved in the release of tumor necrosis factor-related apoptosis-inducing ligand from human neutrophils.
Infection and immunity Mar, 2007 | Pubmed ID: 17194806
Histone deacetylase inhibitors enhance Ad5-TRAIL killing of TRAIL-resistant prostate tumor cells through increased caspase-2 activity.
Apoptosis : an international journal on programmed cell death Mar, 2007 | Pubmed ID: 17195089
The role of Fas ligand and TNF-related apoptosis-inducing ligand (TRAIL) in the ocular immune response.
Chemical immunology and allergy , 2007 | Pubmed ID: 17264490
Apoptotic cells induce tolerance by generating helpless CD8+ T cells that produce TRAIL.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2007 | Pubmed ID: 17312109
TRAIL death receptor-4 expression positively correlates with the tumor grade in breast cancer patients with invasive ductal carcinoma.
International journal of radiation oncology, biology, physics Nov, 2007 | Pubmed ID: 17512128
Neutrophils and TRAIL: insights into BCG immunotherapy for bladder cancer.
Immunologic research , 2007 | Pubmed ID: 17917057
Predicting bacillus Calmette-Guerin immunotherapy effectiveness.
The Journal of urology Dec, 2007 | Pubmed ID: 17936825
Cytomegalovirus and the role of interferon in the expression of tumor necrosis factor-related apoptosis-inducing ligand in the placenta.
American journal of obstetrics and gynecology Dec, 2007 | Pubmed ID: 18060949
TNF-related apoptosis-inducing ligand (TRAIL) is expressed throughout myeloid development, resulting in a broad distribution among neutrophil granules.
Journal of leukocyte biology Mar, 2008 | Pubmed ID: 18063697
Activation of tumor-specific CD8+ T Cells after intratumoral Ad5-TRAIL/CpG oligodeoxynucleotide combination therapy.
Cancer research Dec, 2007 | Pubmed ID: 18089829
Molecular mechanisms of death ligand-mediated immune modulation: a gene therapy model to prolong islet survival in type 1 diabetes.
Journal of cellular biochemistry Jun, 2008 | Pubmed ID: 18247339
Tumor necrosis factor-related apoptosis inducing ligand-R4 decoy receptor expression is correlated with high Gleason scores, prostate-specific antigen recurrence, and decreased survival in patients with prostate carcinoma.
Urologic oncology Mar-Apr, 2008 | Pubmed ID: 18312935
High levels of endogenous tumor necrosis factor-related apoptosis-inducing ligand expression correlate with increased cell death in human pancreas.
Pancreas May, 2008 | Pubmed ID: 18437085
Role of neutrophils in BCG immunotherapy for bladder cancer.
Urologic oncology Jul-Aug, 2008 | Pubmed ID: 18593617
Influenza-induced expression of functional tumor necrosis factor-related apoptosis-inducing ligand on human peripheral blood mononuclear cells.
Human immunology Oct, 2008 | Pubmed ID: 18723061
CD8 T cells utilize TRAIL to control influenza virus infection.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2008 | Pubmed ID: 18802095
High TRAIL death receptor 4 and decoy receptor 2 expression correlates with significant cell death in pancreatic ductal adenocarcinoma patients.
Pancreas Mar, 2009 | Pubmed ID: 18981952
The use of immunofluorescence in microdissection testicular sperm extraction.
Journal of andrology Sep-Oct, 2009 | Pubmed ID: 19234316
TRAIL gene therapy: from preclinical development to clinical application.
Current gene therapy Feb, 2009 | Pubmed ID: 19275567
Early microrecanalization of vas deferens following biodegradable graft implantation in bilaterally vasectomized rats.
Asian journal of andrology May, 2009 | Pubmed ID: 19349949
[Not Available].
Journal of oncology , 2009 | Pubmed ID: 19547714
Induction of tumor cell apoptosis by TRAIL gene therapy.
Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19565910
Adenovirus-mediated TRAIL gene (Ad5hTRAIL) delivery into pancreatic islets prolongs normoglycemia in streptozotocin-induced diabetic rats.
Human gene therapy Oct, 2009 | Pubmed ID: 19572802
In vivo fluorescence imaging is well-suited for the monitoring of adenovirus directed transgene expression in living organisms.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Jun, 2010 | Pubmed ID: 19789926
TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies.
European journal of pharmacology Dec, 2009 | Pubmed ID: 19836385
Activation-induced CD154 expression abrogates tolerance induced by apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2009 | Pubmed ID: 19841180
TRAIL-deficient mice exhibit delayed regression of retinal neovascularization.
The American journal of pathology Dec, 2009 | Pubmed ID: 19893042
The role of neutrophils and TNF-related apoptosis-inducing ligand (TRAIL) in bacillus Calmette-Guérin (BCG) immunotherapy for urothelial carcinoma of the bladder.
Cancer metastasis reviews Dec, 2009 | Pubmed ID: 19967427
Bacillus Calmette-Guerin immunotherapy for urothelial carcinoma of the bladder.
Immunotherapy Mar, 2009 | Pubmed ID: 20046960
Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2010 | Pubmed ID: 20483771
Conatumumab, a fully human mAb against death receptor 5 for the treatment of cancer.
Current opinion in investigational drugs (London, England : 2000) Jun, 2010 | Pubmed ID: 20496264
Micro-recanalization in a biodegradable graft for reconstruction of the vas deferens is enhanced by sildenafil citrate.
Asian journal of andrology Nov, 2010 | Pubmed ID: 20639908
Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist.
Apoptosis : an international journal on programmed cell death Jan, 2011 | Pubmed ID: 20734142
TRAIL-expressing CD8+ T cells mediate tolerance following soluble peptide-induced peripheral T cell deletion.
Journal of leukocyte biology Dec, 2010 | Pubmed ID: 20807702
NF-κB targeting by way of IKK inhibition sensitizes lung cancer cells to adenovirus delivery of TRAIL.
BMC cancer Oct, 2010 | Pubmed ID: 20977779
Systemic immunological tolerance to ocular antigens is mediated by TRAIL-expressing CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2011 | Pubmed ID: 21169546
Tracing of islet graft survival by way of in vivo fluorescence imaging.
Diabetes/metabolism research and reviews Sep, 2011 | Pubmed ID: 21584921
Immune unresponsiveness to secondary heterologous bacterial infection after sepsis induction is TRAIL dependent.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2011 | Pubmed ID: 21788440
Description of a novel murine model for ileocystoplasty and early histologic changes.
TheScientificWorldJournal Jul, 2011 | Pubmed ID: 21789468
Clinical significance of TRAIL and TRAIL receptors in patients with head and neck cancer.
Head & neck Sep, 2011 | Pubmed ID: 21837697
The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2011 | Pubmed ID: 21940678
The plasticity of regulatory T cell function.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2011 | Pubmed ID: 22013112
Cell death in the maintenance and abrogation of tolerance: the five Ws of dying cells.
Immunity Oct, 2011 | Pubmed ID: 22035838
Effect of Combined Locally Delivered Growth Factors and Systemic Sildenafil Citrate on Microrecanalization in Biodegradable Conduit for Vas Deferens Reconstruction.
Urology Jan, 2012 | Pubmed ID: 22285175
Eradication of metastatic renal cell carcinoma after adenovirus-encoded TNF-related apoptosis-inducing ligand (TRAIL)/CpG immunotherapy.
PloS one , 2012 | Pubmed ID: 22312440
Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2012 | Pubmed ID: 22745381
Therapeutic potential of VIP vs PACAP in diabetes.
Journal of molecular endocrinology Dec, 2012 | Pubmed ID: 22991228
Insulin gene therapy from design to beta cell generation.
Expert reviews in molecular medicine Oct, 2012 | Pubmed ID: 23062285
TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice.
The Journal of experimental medicine Oct, 2012 | Pubmed ID: 23071253
Activation of systemic antitumor immunity via TRAIL-induced apoptosis.
Oncoimmunology Oct, 2012 | Pubmed ID: 23170271
Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2013 | Pubmed ID: 23355736
PMN and anti-tumor immunity--the case of bladder cancer immunotherapy.
Seminars in cancer biology Jun, 2013 | Pubmed ID: 23410637
T-cell-mediated immunity and the role of TRAIL in sepsis-induced immunosuppression.
Critical reviews in immunology , 2013 | Pubmed ID: 23510024
Clinical utility of insulin and insulin analogs.
Islets Mar-Apr, 2013 | Pubmed ID: 23584214
Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer.
Cancers Feb, 2011 | Pubmed ID: 24212631
Intravascular staining for discrimination of vascular and tissue leukocytes.
Nature protocols Jan, 2014 | Pubmed ID: 24385150
Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival.
Cell host & microbe Jan, 2014 | Pubmed ID: 24439895
Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2014 | Pubmed ID: 24646738
GLP-1-mediated gene therapy approaches for diabetes treatment.
Expert reviews in molecular medicine Mar, 2014 | Pubmed ID: 24666581
Effective TRAIL-based immunotherapy requires both plasmacytoid and CD8α dendritic cells.
Cancer immunology, immunotherapy : CII Jul, 2014 | Pubmed ID: 24711083
Minimal changes in the systemic immune response after nephrectomy of localized renal masses.
Urologic oncology Jul, 2014 | Pubmed ID: 24768357
Impact of sepsis on CD4 T cell immunity.
Journal of leukocyte biology Nov, 2014 | Pubmed ID: 24791959
CpG-mediated modulation of MDSC contributes to the efficacy of Ad5-TRAIL therapy against renal cell carcinoma.
Cancer immunology, immunotherapy : CII Nov, 2014 | Pubmed ID: 25143233
Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function.
PloS one , 2014 | Pubmed ID: 25541945
Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2015 | Pubmed ID: 25595784
The frequency of naive and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2015 | Pubmed ID: 25972483
Polymicrobial Sepsis Increases Susceptibility to Chronic Viral Infection and Exacerbates CD8+ T Cell Exhaustion.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2015 | Pubmed ID: 25980007
Exploiting natural anti-tumor immunity for metastatic renal cell carcinoma.
Human vaccines & immunotherapeutics , 2015 | Pubmed ID: 25996049
Therapeutic applications of TRAIL receptor agonists in cancer and beyond.
Pharmacology & therapeutics Nov, 2015 | Pubmed ID: 26343199
Triptolide enhances the tumoricidal activity of TRAIL against renal cell carcinoma.
The FEBS journal Dec, 2015 | Pubmed ID: 26426449
Gut Microbial Membership Modulates CD4 T Cell Reconstitution and Function after Sepsis.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2016 | Pubmed ID: 27448587
CD8 T Cell-Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas.
Cancers Jul, 2016 | Pubmed ID: 27472363
Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity.
Critical reviews in immunology , 2016 | Pubmed ID: 27480902
Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease.
Experimental biology and medicine (Maywood, N.J.) Jan, 2017 | Pubmed ID: 27633573
Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2016 | Pubmed ID: 27798171
Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice.
Cell death & disease Jan, 2017 | Pubmed ID: 28055006
1Department of Urology, University of Minnesota,
2Masonic Cancer Center, University of Minnesota,
3Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota,
4Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine,
5, Simmons Cancer Institute
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