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Kennedy Krieger Institute

4 ARTICLES PUBLISHED IN JoVE

Medicine

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Jennifer L. Keller¹, Nora Fritz^1,2, Chen Chun Chiang¹, Allen Jiang¹, Tziporah Thompson³, Nicole Cornet¹, Scott D. Newsome⁴, Peter A. Calabresi⁴, Kathleen Zackowski^1,2,4

¹Motion Analysis Laboratory, Kennedy Krieger Institute, ²Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, ³Johns Hopkins University School of Medicine, ⁴Department of Neurology, Johns Hopkins University School of Medicine

Hip weakness is a common symptom affecting walking ability in people with multiple sclerosis. Isolated muscle strengthening is a useful method to target specific weaknesses. This protocol describes a progressive resistance-training program using exercise bands to increase hip muscle strength.

Neuroscience

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Michael D. Guthrie¹, Donald L. Gilbert², David A. Huddleston², Ernest V. Pedapati^2,3, Paul S. Horn², Stewart H. Mostofsky⁴, Steve W. Wu²

¹College of Medicine, University of Cincinnati, ²Division of Neurology, Cincinnati Children's Hospital Medical Center, ³Division of Psychiatry, Cincinnati Children's Hospital Medical Center, ⁴Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute

We describe an experimental procedure to quantify excitability and inhibition of primary motor cortex during a motor response inhibition task by using Transcranial Magnetic Stimulation throughout the course of a Stop Signal Task.

Medicine

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Dan Wu¹, Andreia V. Faria¹, Laurent Younes^2,3,4, Christopher A. Ross⁵, Susumu Mori^1,6, Michael I. Miller^2,3,7

¹The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, ²Center for Imaging Science, Johns Hopkins University, ³Institute for Computational Medicine, Johns Hopkins University, ⁴Department of Applied Mathematics and Statistics, Johns Hopkins University, ⁵Division of Neurobiology, Departments of Psychiatry, Neurology, Neuroscience and Pharmacology, and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, ⁶F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, ⁷Department of Biomedical Engineering, Johns Hopkins University

This paper describes a statistical model for volumetric MRI data analysis, which identifies the "change-point" when brain atrophy begins in premanifest Huntington's disease. Whole-brain mapping of the change-points is achieved based on brain volumes obtained using an atlas-based segmentation pipeline of T1-weighted images.

Developmental Biology

Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

Kyla A. Britson^1,2, Aaron D. Black^2,3, Kathryn R. Wagner^1,2,3,4, Thomas E. Lloyd^1,2,4

¹Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, ²Department of Neurology, Johns Hopkins University School of Medicine, ³Kennedy Krieger Institute, ⁴Department of Neuroscience, Johns Hopkins University School of Medicine

Complex human diseases can be challenging to model in traditional laboratory model systems. Here, we describe a surgical approach to model human muscle disease through the transplantation of human skeletal muscle biopsies into immunodeficient mice.