Name: adapted resistance training improves strength in eight weeks in individuals with multiple sclerosis
Uploaded: 2016-01-29T15:00:00.000+00:00
Duration: 8 min 48 s
Description: Watch this Scientific Journal Video about Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis at JoVE.com

저자는 고맙게도 Rhul Marasigan 및 연구에 모든 참가자를 인정하고 싶습니다. 운동 그림은 Tziporah 톰슨에 의해 제공되었다.

<ol>
	<li>Sutliff, M. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Contribution+of+impaired+mobility+to+patient+burden+in+multiple+sclerosis.">Contribution of impaired mobility to patient burden in multiple sclerosis.</a> Curr Med Res Opin. 26 (1), 109-119 (2010).</li><li>Zwibel, H. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Contribution+of+impaired+mobility+and+general+symptoms+to+the+burden+of+multiple+sclerosis.">Contribution of impaired mobility and general symptoms to the burden of multiple sclerosis.</a> Adv Ther. 26 (12), 1043-1057 (2009).</li><li>Fritz, N. E., Newsome, S. D., Eloyan, A., Marasigan, R. E. R., Calabresi, P. A., Zackowski, K. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Longitudinal+relationships+among+posturography+and+gait+measures+in+multiple+sclerosis.">Longitudinal relationships among posturography and gait measures in multiple sclerosis.</a> Neurology. 84 (20), 2048-2056 (2015).</li><li>Zackowski, K. M., Wang, J. L., McGready, J., Calabresi, P. A., Newsome, S. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Quantitative+sensory+and+motor+measures+detect+change+over+time+and+correlate+with+walking+speed+in+individuals+with+multiple+sclerosis.">Quantitative sensory and motor measures detect change over time and correlate with walking speed in individuals with multiple sclerosis.</a> Mult Scler Relat Disor.4(1):67-71. 4 (1), 67-71 (2015).</li><li>Keller, J. L., Wang, J. I., Kang, J. Y., Hanson, J. A., Kamath, P., Swain, J. O., Raymond, G. V., Zackowski, K. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Strength:+A+relevant+link+to+functional+performance+in+the+neurodegenerative+disease+of+adrenomyeloneuropathy.">Strength: A relevant link to functional performance in the neurodegenerative disease of adrenomyeloneuropathy.</a> Neurorehabil Neural Repair. 26 (9), 1080-1088 (2012).</li><li>Shahrbanian, S., Dugette, P., Kuspinar, A., Mayo, N. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Contribution+of+symptom+clusters+to+multiple+sclerosis+consequences.">Contribution of symptom clusters to multiple sclerosis consequences.</a> Qual Life Res. 24 (3), 617-629 (2015).</li><li>Motl, R. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Physical+activity+and+irreversible+disability+in+multiple+sclerosis.">Physical activity and irreversible disability in multiple sclerosis.</a> Exerc Sport Sci Rev. 38 (4), 186-191 (2010).</li><li>Mostert, S., Kesselring, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Effects+of+a+short-term+exercise+training+program+on+aerobic+fitness,+fatigue,+health+perception+and+activity+level+of+subjects+with+multiple+sclerosis.">Effects of a short-term exercise training program on aerobic fitness, fatigue, health perception and activity level of subjects with multiple sclerosis.</a> Mult Scler. 8 (2), 161-168 (2002).</li><li>Newman, M. A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Can+aerobic+treadmill+training+reduce+the+effort+of+walking+and+fatigue+in+people+with+multiple+sclerosis:+a+pilot+study).">Can aerobic treadmill training reduce the effort of walking and fatigue in people with multiple sclerosis: a pilot study).</a> Mult Scler. 13 (1), 113-119 (2007).</li><li>Dalgas, U., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Muscle+fiber+size+increases+following+resistance+training+in+multiple+sclerosis).">Muscle fiber size increases following resistance training in multiple sclerosis).</a> Mult Scler. 16 (11), 1367-1376 (2010).</li><li>Dalgas, U., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Fatigue,+mood+and+quality+of+life+improve+in+MS+patients+after+progressive+resistance+training.">Fatigue, mood and quality of life improve in MS patients after progressive resistance training.</a> Mult Scler. 16 (4), 480-490 (2010).</li><li>Gutierrez, G. M., Chow, J. W., Tillman, M. D., McCoy, S. C., Castellano, V., White, L. I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Resistance+training+improves+gait+kinematics+in+persons+with+multiple+sclerosis.">Resistance training improves gait kinematics in persons with multiple sclerosis.</a> Arch Phys Med Rehabil. 86 (9), 1824-1829 (2005).</li><li>Kj&#248;lhede, T., Vissing, K., de Place, L., Pedersen, B. G., Ringgaard, S., Stenager, E., Petersen, T., Dalgas, U. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Neuromuscular+adaptations+to+long-term+progressive+resistance+training+translates+to+improved+functional+capacity+for+people+with+multiple+sclerosis+and+is+maintained+at+follow-up.">Neuromuscular adaptations to long-term progressive resistance training translates to improved functional capacity for people with multiple sclerosis and is maintained at follow-up.</a> Mult Scler. 21 (5), 599-611 (2015).</li><li>Kj&#248;lhede, T., Vissing, K., Dalgas, U. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Multiple+sclerosis+and+progressive+resistance+training:+a+systematic+review.">Multiple sclerosis and progressive resistance training: a systematic review.</a> Mult Scler. 18 (9), 1215-1228 (2012).</li><li>Dalgas, U., Stenager, E., Lund, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Neural+drive+increases+following+resistance+training+in+patients+with+multiple+sclerosis.">Neural drive increases following resistance training in patients with multiple sclerosis.</a> J Neurol. 260 (7), 1822-1832 (2013).</li><li>Dalgas, U., Stenager, E., Jakobsen, J., Petersen, T., Hansen, H. J., Knudsen, C., Overgaard, K., Ingemann-Hansen, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Resistance+training+improves+muscle+strength+and+functional+capacity+in+multiple+sclerosis.">Resistance training improves muscle strength and functional capacity in multiple sclerosis.</a> Neurology. 73 (18), 1478-1484 (2009).</li><li>Kurtzke, J. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+new+scale+for+evaluating+disability+in+multiple+sclerosis.">A new scale for evaluating disability in multiple sclerosis.</a> Neurology. 5 (8), 580-583 (1955).</li><li>Kurtzke, J. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Rating+neurologic+impairments+in+multiple+sclerosis:+an+expanded+disability+status+scale+(EDSS).">Rating neurologic impairments in multiple sclerosis: an expanded disability status scale (EDSS).</a> Neurology. 33 (11), 1444-1452 (1983).</li><li>Sahrmann, S. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> Diagnosis and Treatment of Movement Impairment Syndromes. , (2002).</li><li>Bohannon, R. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Reference+values+for+extremity+muscle+strength+obtained+by+hand-held+dynamometry+from+adults+aged+20+to+79+years.">Reference values for extremity muscle strength obtained by hand-held dynamometry from adults aged 20 to 79 years.</a> Arch Phys Med Rehabil. 78 (1), 26-32 (1997).</li><li>Newsome, S. D., Wang, J. Y., Kang, J. Y., Calabresi, P. A., Zackowski, K. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Quantitative+measures+detect+sensory+and+motor+impairments+in+multiple+sclerosis.">Quantitative measures detect sensory and motor impairments in multiple sclerosis.</a> J Neuro Sci. 305 (1-2), 103-111 (2011).</li><li>Hackney, M., McKee, K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Community-based+adapted+tango+dancing+for+individuals+with+Parkinson's+Disease+and+older+adults.">Community-based adapted tango dancing for individuals with Parkinson's Disease and older adults.</a> JoVE. (94), e1-e12 (2014).</li></ol>

금융 공개 / 이해 상충은 :보고 관심 없음 충돌이 없습니다. 소스를 자금 : 국립 다발성 경화증 학회에서 연구 보조금을.

이 프로토콜은 고립 된 근육 다발성 경화증 환자에 대한 저항 밴드와 강화를 사용하여 진보적 인 저항 훈련 프로그램을 설명합니다. 이 프로토콜은 강도 제한 ambulate과 삶의 질을 유지하기 위해 자신의 능력을 손상 할 수있다 퇴행성 조건과 개인에 대한 고유 한 기능을 가지고 있습니다. 초점은 MS (21)의 보행 속도에 중요한 낮은 사지의 근위부 근력 향상에 4. 이 프로토콜의 장점 ?...

MS에서, 손상된 신경 기능은 일반적으로 약점의 결과로, 모터의 기능 장애로 이어집니다. 그것은 근육 약화가 MS와 활동 더 타협 기능 능력 1 명에서 감소 일상 생활에 기여하는 것으로 알려져있다 2. 우리 연구소는 MS와 개인에 약한 엉덩이 굴근 근육이 특히 약한 개인 4, 속도 3 걷는 영향을 미치는 것으로 나타났습니다. 보행에 약한 근위 엉덩이 근육의 중요성은 MS에서뿐만 아니라 다른 신경 퇴행성 조건 4에 도시 된 5. 이 악순환의 고리가 증가 장애 및 생활 6의 감소 품질에 기여 7. (9), 근력 (10), 피로 (8); 규칙적인 운동은 일상 생활 (8), 심장 혈관 피트니스 8을 향상시킬 수 11 명에서 MS (12). 강도 훈련은 MS 참가자 13-16에서 유리한 기능적 결과로 이어질 수 신경 적응을 촉진하는 것으로 알려져. &amp; #된다160; 재활 기능의 복구를 위해 MS를 가진 개인에게 제공되는 유일한 치료가 종종 있기 때문에, 그 강도를 향상시킬 수있는 가장 효율적인 방법을 결정하는 것이 중요하다. 저항 강도 훈련은 근육의 강도 강화를 최적화하기위한 최선의 방법에 중요한 변경 사항을 확인하는 데 필요한 시간의 최소 금액에 대한 명확한 합의로 평가되고있다. 현재 검토는 저항 훈련의 연구는 주로 MS가 (0-6.5의 확장 장애 상태 규모) 장애를 완화하기 위해 낮은에서 14 고통을 가진 사람들의 하반신을 대상으로, 3~26주 길이 변화 한 것을보고 17 18 . 이러한 연구들은 주로 체육관 위치에 직접적인 감독과 훈련을 위해 등속 장치를 사용합니다. 등속 성 장비의 사용은 분리하고 단일 근육을 강화하는 하나의 방법이지만, 고가의 장비를 사용하지 않고 운동을 완료하는 사람의 능력을 제한항상 액세스 할 수 없습니다. 저항 밴드함으로써, 저항의 방향뿐만 아니라, 다리에 저항의 배치를 제어하는​​ 말초 관절 응력을 회피하는 장점을 제공한다. 저항 밴드는 또한 팔목 무게로 등급에 기회를 다른 장비와 다음 미세한 단위로 저항을 제공합니다. 정렬 및 이동 패턴을주의 깊게 운동 선수의 훈련에서 해결 된, 아직 한계가 너무 복잡해서 (예를 들면, 감각, 모터 제어,인지) 때문에 약간의주의를 부분적으로 만성 변성 조건을 가진 개인에 이러한 요소에 주어진다. 운동에 배향 주소뿐만 아니라 일상 생활에서 필요 19 중요하다. 간단하지만 정확하게 그대로 신경계 (19)를 가진 개인의 근골격계 증후군의 해결에 도움을 수행하는 훈련을 잘 선택. 많은 일반 운동 프로그램이 있지만 available가, 그들은 질병의 진보적 특성상, 이동 및 수정 필요에 영향을 미칠 MS의 특정 장애를 해결하지 않습니다. 이 프로그램을 위해, 우리는 자세 맞춤뿐만 아니라 근육이 기능적으로 사용되는 방식에 가장 최적의 위치에서 수행되는 특정 운동을 강조한다. 이 연구의 목적은 장애의 변수도 개인에 일반화되는 엉덩이 근육에 대한 접근, 저렴, 저항 훈련 프로그램을 만드는 것이 었습니다. 단순하지만 정확하게 설명 고관절 강화 운동은 고립 된 근육의 강화를 강조하고 여기에 적응하고 가이드 라인은 더 현재의 근력에 따라 운동을 적응하는 개인을 위해 제공됩니다. 개인이 가정 및 지정된 프로그램을 복제하는 데 필요한 세부 사항에 쉽게 적용 할 수있는 체계적인 방법으로 저항 밴드와 함께 운동을 할 수 있도록 권장 만들어집니다.

<table><tbody><tr><td>microFET2</td><td>Hoggan Scientific, LLC</td><td></td><td>Digital hand held muscle tester</td></tr><tr><td>REP Bands (all colors)</td><td>Power Systems</td><td>5600-011</td><td>Resistance bands for the exercise program</td></tr><tr><td>TheraBand Latex-Free Exercise Bands (all colors)</td><td>TheraBand</td><td>11726-11730</td><td>Resistance bands for the exercise program</td></tr><tr><td>8&#039;&#039; Cable Ties</td><td>Lowes Home Improvement</td><td>76329</td><td>Tied into the resistance bands to provide places for the carabiner to clip onto</td></tr><tr><td>Door Anchor</td><td>GoFit</td><td></td><td>Anchors the REP bands to doors</td></tr><tr><td>Hollow-Braid Poly Rope</td><td>Home Depot</td><td>140538</td><td>Anchors REP bands to table legs/other fixtures</td></tr><tr><td>Zinc-Plated Steel Hang All</td><td>Home Depot</td><td>550768</td><td>Thigh straps for the hip exercises</td></tr><tr><td>Neoprene Ankle Strap</td><td>TKO</td><td>106 BK</td><td>Ankle strap for leg exercises</td></tr><tr><td>Positron Carabiner</td><td>Black Diamond</td><td>BD2102610000ALL1</td><td>Carabiners to link ankle/thigh strap to REP bands</td></tr><tr><td>Fitness Gear 3mm Mat</td><td>Dick&#039;s Sporting Goods</td><td>41857546</td><td>Yoga mat for exercises on the ground</td></tr><tr><td>1/2 inch, 2 by 2 Exercise Tiles</td><td>FoamTiles</td><td></td><td>Gym matting for exercies on the ground</td></tr><tr><td>Spirit LT Portable Massage Table</td><td>EarthLite</td><td></td><td>Table for hip extension and other exercises that required a raised platform</td></tr><tr><td>Performa Treatment Table</td><td>Sammons Preston</td><td>553736</td><td>Heavy treatment table for testing/anchoring REP bands</td></tr><tr><td>STATA SE 11</td><td>STATA</td><td></td><td>Software for statistical analysis</td></tr><tr><td>STATISTICA</td><td>Dell Software</td><td></td><td>Software for statistical analysis</td></tr></tbody></table>

adapted resistance training improves strength in eight weeks in individuals with multiple sclerosis

엉덩이 약점은 다발성 경화증 (MS) 환자의 보행 능력에 영향을 미치는 일반적인 증상이다. 이것은 저항 근력 트레이닝 (RST)가 MS 그러나, 개인의 강도를 향상시킬 수 있다고 알려져있다; 그것은 힘의 이득을 만들기 위해 필요한 방법 만 저항 밴드를 사용하여 다양한 강도의 개인 고관절 강화 운동을 적응하기 위해 RST의 기간 확실하지 않다. 이 논문은 설정 및 MS와 개인을 위해, 저항 밴드를 사용하여, 적응 저항 강도 훈련 프로그램을 구현하는 방법을 설명합니다. 사전 및 사후 강도 시험에 대한 방향은 강도 훈련 프로그램의 효과가 포함되어보고자 하였다. 안전 기능과 자세한 설명은 주간 프로그램 내용 및 진행을 설명합니다. 현재의 증거는 상당한 강도 이득 RST 프로그램 개시 8 주 이내에 이루어질 수 있음을 보여주는 제시된다. 증거는 그 저항 강도 훈련이 성공적으로 adapte 수 있습니다 보여주는 제시작은 장비와 강도를 변화의 MS와 개인에 대한 D.

우리는 우리의 시설에서 1​​2 주 하체 진보, 저항 훈련 (PRT)에 참여 MS와 (26) 개인의 결과를 보여줍니다. 우리의 참가자들은 4.0의 평균 EDSS (범위 : 1-6.5)와 장애의 수준을 변화 한 시대의 평균 50.0 (11.3) 년 (막내가 가장 오래된 64 년 23 년), (17)가 여성이며,이 있습니다 12.5 (8.7) 년의 평균 증상 기간. 그림 1은 엉덩이 강도 훈련의 12 주 (모든 엉덩이 근육 P &lt;0.005) 다?...

Watch this Scientific Journal Video about Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis at JoVE.com

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

엉덩이 약점은 다발성 경화증 환자의 보행 능력에 영향을 미치는 일반적인 증상이다. 고립 된 근육 강화는 특정 약점을 대상으로하는 유용한 방법이다. 이 프로토콜은 엉덩이 근육 강도를 증가시키기 위해 운동 밴드를 이용하여 프로그레시브 저항 훈련 프로그램을 설명한다.

적응 저항 훈련은 다발성 경화증을 가진 개인에 여덟 주에서 강도를 향상

Hip weakness is a common symptom affecting walking ability in people with multiple sclerosis (MS). It is known that resistance strength training (RST) can ...

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JoVE Journal

Medicine

16.7K 조회수.  Kennedy Krieger Institute.  엉덩이 약점은 다발성 경화증 환자의 보행 능력에 영향을 미치는 일반적인 증상이다. 고립 된 근육 강화는 특정 약점을 대상으로하는 유용한 방법이다. 이 프로토콜은 엉덩이 근육 강도를 증가시키기 위해 운동 밴드를 이용하여 프로그레시브 저항 훈련 프로그램을 설명한다. 

비디오: Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach

Inclusion body myositis (IBM) is a rare idiopathic inflammatory myopathy. It is known to produces remarkable muscle weakness and to greatly compromise function and quality of life. Moreover, clinical practice suggests that, unlike other inflammatory myopathies, the majority of IBM patients are not responsive to treatment with immunosuppressive or immunomodulatory drugs to counteract disease progression1. Additionally, conventional resistance training programs have been proven ineffective in restoring muscle function and muscle mass in these patients2,3. Nevertheless, we have recently observed that restricting muscle blood flow using tourniquet cuffs in association with moderate intensity resistance training in an IBM patient produced a significant gain in muscle mass and function, along with substantial benefits in quality of life4. Thus, a new non-pharmacological approach for IBM patients has been proposed. Herein, we describe the details of a proposed protocol for vascular occlusion associated with a resistance training program for this population.

The present article presents the details pertaining to the application of resistance training associated to vascular occlusion in IBM patients.

포함 바디 Myositis에 대한 혈관의 폐색 교육 : 소설 치료 접근

Inclusion body myositis (IBM) is a rare idiopathic inflammatory myopathy. It is known to produces remarkable muscle weakness and to greatly compromise ...

연구

의학

A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation

Neuromuscular electrical stimulation (NMES) is a common clinical modality that is widely used to restore1, maintain2 or enhance3-5 muscle functional capacity. Transcutaneous surface stimulation of skeletal muscle involves a current flow between a cathode and an anode, thereby inducing excitement of the motor unit and the surrounding muscle fibers. 
NMES is an attractive modality to evaluate skeletal muscle adaptive responses for several reasons. First, it provides a reproducible experimental model in which physiological adaptations, such as myofiber hypertophy and muscle strengthening6, angiogenesis7-9, growth factor secretion9-11, and muscle precursor cell activation12 are well documented. Such physiological responses may be carefully titrated using different parameters of stimulation (for Cochrane review, see 13). In addition, NMES recruits motor units non-selectively, and in a spatially fixed and temporally synchronous manner14, offering the advantage of exerting a treatment effect on all fibers, regardless of fiber type. Although there are specified contraindications to NMES in clinical populations, including peripheral venous disorders or malignancy, for example, NMES is safe and feasible, even for those who are ill and/or bedridden and for populations in which rigorous exercise may be challenging. 
Here, we demonstrate the protocol for adapting commercially available electrodes and performing a NMES protocol using a murine model. This animal model has the advantage of utilizing a clinically available device and providing instant feedback regarding positioning of the electrode to elicit the desired muscle contractile effect. For the purpose of this manuscript, we will describe the protocol for muscle stimulation of the anterior compartment muscles of a mouse hindlimb.

A murine model of neuromuscular electrical stimulation (NMES), a safe and inexpensive clinical modality, to the anterior compartment muscles is described. This model has the advantage of modifying a readily available clinical device for the purpose of eliciting targeted and specific muscle contractions in mice.

신경근육학 전기적 자극에 의​​해 근육 트레이닝의 Murine 모델

Neuromuscular electrical stimulation (NMES) is a common clinical modality that is widely used to restore1, maintain2 or enhance3-5 muscle functional ...

Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury

Skeletal muscle atrophy, increased adiposity and reduced physical activity are key changes observed after spinal cord injury (SCI) and are associated with numerous cardiometabolic health consequences. These changes are likely to increase the risk of developing chronic secondary conditions and impact the quality of life in persons with SCI. Surface neuromuscular electrical stimulation evoked resistance training (NMES-RT) was developed as a strategy to attenuate the process of skeletal muscle atrophy, decrease ectopic adiposity, improve insulin sensitivity and enhance mitochondrial capacity. However, NMES-RT is limited to only a single muscle group. Involving multiple muscle groups of the lower extremities may maximize the health benefits of training. Functional electrical stimulation-lower extremity cycling (FES-LEC) allows for the activation of 6 muscle groups, which is likely to evoke greater metabolic and cardiovascular adaptation. Appropriate knowledge of the stimulation parameters is key to maximizing the outcomes of electrical stimulation training in persons with SCI. Adopting strategies for long-term use of NMES-RT and FES-LEC during rehabilitation may maintain the integrity of the musculoskeletal system, a pre-requisite for clinical trials aiming to restore walking after injury. The current manuscript presents a combined protocol using NMES-RT prior to FES-LEC. We hypothesize that muscles conditioned for 12 weeks prior to cycling will be capable of generating greater power, cycle against higher resistance and result in greater adaptation in persons with SCI.

Spinal cord injury is a traumatic medical condition that may result in elevated risks of chronic secondary metabolic disorders. Here, we presented a protocol using surface neuromuscular electrical stimulation-resistance training in conjunction with functional electrical stimulation-lower extremities cycling as a strategy to ameliorate several of these medical problems.

척수 손상 후 더 낮은 말단 전기 자극 교육의 패러다임

Skeletal muscle atrophy, increased adiposity and reduced physical activity are key changes observed after spinal cord injury (SCI) and are associated with ...

행동분석학

Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study

Execution of Sit-to-Stand (SitTS) in incomplete spinal cord injury (SCI) patients involves motor function in both upper and lower extremities. The use of arm support, in particular, is a significant assistive factor while executing SitTS movement in SCI population. In addition, the application of functional electrical stimulation (FES) onto quadriceps and gluteus maximus muscles is one of the prescribed management for incomplete SCI to improve muscle action for simple lower limb movements. However, the relative contribution of upper and lower extremities during SitTS has not been thoroughly investigated. Two motor incomplete SCI paraplegics performed repetitive SitTS to fatigue exercise challenge. Their performance was investigated as a mixed-method case-control study comparing SitTS with and without the assistance of FES. Three sets of SitTS tests were completed with 5-min resting period allocated in between sets, with mechanomyography (MMG) sensors attached over the rectus femoris muscles bilaterally. The exercise was separated into 2 sessions; Day 1 for voluntary SitTS and Day 2 for FES-assisted SitTS. Questionnaires were conducted after every session to gather the participants&#39; input about their repetitive SitTS experience. The analysis confirmed that a SitTS cycle could be divided into three phases; Phase 1 (Preparation to stand), Phase 2 (Seat-off), and Phase 3 (Initiation of hip extension), which contributed to 23% &#177; 7%, 16% &#177; 4% and 61% &#177; 6% of the SitTS cycle, respectively. The contribution of arms and legs during SitTS movement varied in different participants based on their legs&#39; Medical Research Council (MRC) muscle grade. In particular, the applied arm forces start to increase clearly when the leg forces start to decline during standing. This finding is supported by the significantly reduced MMG signal indicating leg muscle fatigue and their reported feeling of tiredness.

Arms contribution in Sit-To-Stand (SitTS) is determined by the legs' muscle condition. Several compensating strategies were discovered in efforts to achieve complete SitTS cycles. These findings triangulate the spinal cord injury (SCI) persons' biomechanical measures with their subjective feeling of load borne by both their limbs throughout the SitTS approaches.

하반신 마비 환자에서 반복적인 전기 보조 기립 운동 중 팔과 다리 기여도 정량화: 파일럿 연구

Execution of Sit-to-Stand (SitTS) in incomplete spinal cord injury (SCI) patients involves motor function in both upper and lower extremities. The use of ...

공학

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

This protocol describes the simultaneous use of a broad span of methods to examine muscle aerobic capacity, glucose tolerance, strength, and power in elderly people performing short-term resistance training (RET). Supervised progressive resistance training for 1 h three times a week over 8 weeks was performed by RET participants (71&#177;1 years, range 65-80). Compared to a control group without training, the RET showed improvements on the measures used to indicate strength, power, glucose tolerance, and several parameters of muscle aerobic capacity. Strength training was performed in a gym with only robust fitness equipment. An isokinetic dynamometer for knee extensor strength permitted the measurement of concentric, eccentric, and static strength, which increased for the RET group (8-12% post- versus pre-test). The power (rate of force development, RFD) at the initial 0-30 ms also showed an increase for the RET group (52%). A glucose tolerance test with frequent blood glucose measurements showed improvements only for the RET group in terms of blood glucose values after 2 h (14%) and the area under the curve (21%). The blood lipid profile also improved (8%). From muscle biopsy samples prepared using histochemistry, the amount of fiber type IIa increased, and a trend towards a decrease in IIx in the RET group reflected a change to a more oxidative profile in terms of fiber composition. Western blot (to determine the protein content related to the signaling for muscle protein synthesis) showed a rise of 69% in both Akt and mTOR in the RET group; this also showed an increase in mitochondrial proteins for OXPHOS complex II and citrate synthase (both ~30%) and for complex IV (90%), in only the RET group. We demonstrate that this type of progressive resistance training offers various improvements (e.g., strength, power, aerobic capacity, glucose tolerance, and plasma lipid profile).

The effect of short-term resistance training on elderly people was investigated through the simultaneous use of several methods. Compared to a control group, many improvements were seen, including on muscle aerobic capacity, glucose tolerance, strength, power, and muscle quality (i.e., protein involved in cell signaling and muscle fiber type composition).

This protocol describes the simultaneous use of a broad span of methods to examine muscle aerobic capacity, glucose tolerance, strength, and power in ...

A Training Program Using an Agility Ladder for Community-Dwelling Older Adults

Aging impairs physical and cognitive functions and limits daily activities. Agility training can improve or maintain physical functioning in older people. The purpose of this study is to report the physical fitness benefits of a training program for independent community-dwelling older adults using an agility ladder. Each training session lasted approximately 30 minutes, and the benefits were achieved with two sessions per week for 14 weeks. Training was timed and involved four different drills and varying levels of difficulty through time. The exercises were performed at the School of Physical Education of the University of Campinas, S&#227;o Paulo state, Brazil. The study participants (n = 16; mean age of 66.9 &#177; 5.0 years) were instructed to perform the exercises as quickly as possible without making mistakes and were assisted by a physical trainer when they made mistakes. Assessments were performed both before and after training using five functional tests (i.e., Illinois agility, five times sit-to-stand, timed up-and-go, walking usual speed, and one-leg stand). Although the study sample was not compared with a control group, the results indicate that training protocols using an agility ladder are easy and practical and improve physical function performance in older adults.

The aim of this study is to present an agility training program for older people. The feasibility of this program is described, and the training protocol demonstrated by video imaging.

지역 사회 거주 노인을위한 민첩성 사다리를 사용하는 교육 프로그램

Aging impairs physical and cognitive functions and limits daily activities. Agility training can improve or maintain physical functioning in older people. ...

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Progressive resistance training (PRT), which involves performing muscle contractions against progressively greater external loads, can increase muscle mass and strength in healthy individuals and in patient populations. There is a need for precision rehabilitation tools to test the safety and effectiveness of PRT to maintain and/or restore muscle mass and strength in preclinical studies on small and large animal models. The PRT methodology and device described in this article can be used to perform dosage-adjusted resistance training (DART). The DART device can be used as a standalone dynamometer to objectively assess the concentric contractile torque generated by the ankle dorsiflexors in mice or can be added to a pre-existing isokinetic dynamometry system. The DART device can be fabricated with a standard 3D printer based on the instructions and open-source 3D print files provided in this work. The article also describes the workflow for a study to compare contraction-induced muscle damage caused by a single bout of DART to muscle damage caused by a comparable bout of isometric contractions (ISOM) in a mouse model of limb-girdle muscular dystrophy type 2B/R2 (BLAJ mice). The data from eight BLAJ mice (four animals for each condition) suggest that less than 10% of the tibialis anterior (TA) muscle was damaged from a single bout of DART or ISOM, with DART being less damaging than ISOM.

The present protocol describes a unique technique called dosage-adjusted resistance training (DART), which can be incorporated into precision rehabilitation studies performed in small animals, such as mice.

근육 손상 위험이 감소한 마우스에서 복용량 조정 저항 훈련

Progressive resistance training (PRT), which involves performing muscle contractions against progressively greater external loads, can increase muscle ...

신경과학

근력 운동량과 비만에서 인슐린 감수성에 미치는 영향 평가

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

An acute session of strength exercise (SE) ameliorates insulin sensitivity (IS) for several hours; however, the effects of SE volume (i.e., number of sets) have not been studied thoroughly. Although it is intuitive that some SE is better than none, and more is better than some for the improvement of IS, high-volume sessions might be challenging for diseased populations to complete, especially obese adults, for whom even a brisk walk can be challenging. This protocol details a randomized clinical trial to assess the acute effects of SE on IS in obese adults. The inclusion criteria are body mass index &#62;30 kg/m2, central obesity (waist circumference &#62;88 cm and &#62;102 cm for women and men, respectively), and age &#62;40 years. Participants will be familiarized with the SE (7 exercises targeting major muscle groups) and then will perform three sessions in a randomized order: session 1 - high-volume session (3 sets/exercise); session 2 - low-volume session (1 set/exercise); session 3 - control session (no exercise). Diet will be controlled the day before and on the day of the sessions. Sessions will be completed at night, and an oral glucose tolerance test will be performed the next morning, from which several indexes of IS will be derived, such as the area under the curve (AUC) of glucose and insulin, the Matsuda index, the Cederholm index, the muscle IS index, and the Gutt index. Based on pilot studies, we expect ~15% improvement in IS (insulin AUC, and Matsuda and Cederholm indexes) after the high-volume session, and ~8% improvement after the low-volume session compared to the control session. This study will benefit individuals who find high-volume SE sessions challenging but still aim to improve their IS by investing 1/3 of their time and effort.

저자 스포트라이트: 저항력 운동량 감소가 신진대사 건강에 미치는 영향 탐구 

This study describes a randomized controlled trial protocol aiming at assessing the acute effects of strength exercise volume on insulin sensitivity in obese individuals.

비만 성인의 인슐린 감수성에 대한 근력 운동의 급성 효과를 연구하기 위한 무작위 대조 시험

An acute session of strength exercise (SE) ameliorates insulin sensitivity (IS) for several hours; however, the effects of SE volume (i.e., number of ...

적응 저항 훈련은 다발성 경화증을 가진 개인에 여덟 주에서 강도를 향상

요약

더 많은 비디오 탐색

이 비디오의 챕터

포함 바디 Myositis에 대한 혈관의 폐색 교육 : 소설 치료 접근

신경근육학 전기적 자극에 의해 근육 트레이닝의 Murine 모델

척수 손상 후 더 낮은 말단 전기 자극 교육의 패러다임

하반신 마비 환자에서 반복적인 전기 보조 기립 운동 중 팔과 다리 기여도 정량화: 파일럿 연구

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

지역 사회 거주 노인을위한 민첩성 사다리를 사용하는 교육 프로그램

근육 손상 위험이 감소한 마우스에서 복용량 조정 저항 훈련

비만 성인의 인슐린 감수성에 대한 근력 운동의 급성 효과를 연구하기 위한 무작위 대조 시험

비만 성인의 인슐린 감수성에 대한 근력 운동의 급성 효과를 연구하기 위한 무작위 대조 시험

비만 성인의 인슐린 감수성에 대한 근력 운동의 급성 효과를 연구하기 위한 무작위 대조 시험

적응 저항 훈련은 다발성 경화증을 가진 개인에 여덟 주에서 강도를 향상

요약

더 많은 비디오 탐색

이 비디오의 챕터

포함 바디 Myositis에 대한 혈관의 폐색 교육 : 소설 치료 접근

신경근육학 전기적 자극에 의​​해 근육 트레이닝의 Murine 모델

척수 손상 후 더 낮은 말단 전기 자극 교육의 패러다임

하반신 마비 환자에서 반복적인 전기 보조 기립 운동 중 팔과 다리 기여도 정량화: 파일럿 연구

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

지역 사회 거주 노인을위한 민첩성 사다리를 사용하는 교육 프로그램

근육 손상 위험이 감소한 마우스에서 복용량 조정 저항 훈련

비만 성인의 인슐린 감수성에 대한 근력 운동의 급성 효과를 연구하기 위한 무작위 대조 시험

비만 성인의 인슐린 감수성에 대한 근력 운동의 급성 효과를 연구하기 위한 무작위 대조 시험

비만 성인의 인슐린 감수성에 대한 근력 운동의 급성 효과를 연구하기 위한 무작위 대조 시험

신경근육학 전기적 자극에 의해 근육 트레이닝의 Murine 모델