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University of Turku and Åbo Akademi University

2 ARTICLES PUBLISHED IN JoVE

Biochemistry

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Mahlet Z. Tamirat¹, Kari J. Kurppa², Klaus Elenius^2,3,4, Mark S. Johnson¹

¹Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, ²Medicity Research Laboratories and Institute of Biomedicine, University of Turku, ³Turku Bioscience Centre, University of Turku and Åbo Akademi University, ⁴Department of Oncology and Radiotherapy, University of Turku and Turku University Hospital

The objective of this protocol is to use molecular dynamics simulations to examine the dynamic structural changes that occur due to activating mutations of the EGFR kinase protein.

Medicine

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia

Rüdiger Schultz^1,2, Tiina Peromaa³, Heikki Lukkarinen², Varpu Elenius²

¹Allergy Centre, Tampere University Hospital, ²Department of Pediatrics, Turku University Hospital, ³Turku Bioscience Center, University of Turku and Åbo Akademi University

High-speed video microscopy analysis is a relatively easy-to-perform, fast, cost-effective, and, in experienced hands, a considerably reliable tool for first-line diagnostics of primary ciliary dyskinesia, which should be available in every center involved in diagnostics and the treatment of severe lung diseases.