May 21st, 2010
•We describe a protocol for the rapid and sensitive quantification of disease severity in mouse models of cerebellar ataxia. Measures include hind limb clasping, ledge test, gait and kyphosis. This protocol effectively discriminates between affected and non-affected individuals, and detects the progression of affected individuals over time.
Related Videos
Mouse Models of Periventricular Leukomalacia
Organotypic Cerebellar Cultures: Apoptotic Challenges and Detection
Quantitative Analysis of Synaptic Vesicle Pool Replenishment in Cultured Cerebellar Granule Neurons using FM Dyes
A General Method for Evaluating Incubation of Sucrose Craving in Rats
Laser Nanosurgery of Cerebellar Axons In Vivo
Olfactory Assays for Mouse Models of Neurodegenerative Disease
Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
Transplantation of Chemogenetically Engineered Cortical Interneuron Progenitors into Early Postnatal Mouse Brains
Assessment of Long-term Depression Induction in Adult Cerebellar Slices
Cerebellar Regional Dissection for Molecular Analysis
Copyright © 2024 MyJoVE Corporation. 판권 소유