A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

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07:33 min

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May 21st, 2010

DOI :

May 21st, 2010

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Stephan J. Guyenet¹, Stephanie A. Furrer², Vincent M. Damian¹, Travis D. Baughan², Albert R. La Spada*³, Gwenn A. Garden*²

¹Department of Biochemistry, University of Washington, ²Department of Neurology, University of Washington, ³Division of Genetics, Departments of Pediatrics and Cellular and Molecular Medicine, and the Institute for Genomic Medicine, University of California, San Diego - Rady Children’s Hospital

Summary

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Composite Phenotype Scoring System

Cerebellar Ataxia

Phenotype Assessments

Disease Severity

Hind Limb Clasping

Neurodegenerative Disease Phenotypes

Temporal Progression

Transgenic Mouse Model

Spinocerebellar Ataxia Type 7 SCA7

Albert R La Spada

Chapters in this video

0:00

Title

1:22

Introduction

1:58

Ledge Test

3:25

Hindlimb Clasping

4:19

Gait Test

6:17

Representative Assessment Results

6:52

Conclusion

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