우리는 보조금 CMMI 0,854,881 및 1,066,898 CBET을 통해 NSF에서 자금을 인정합니다. 저자 도움이 제안 매튜의 Mullens 감사드립니다.

<ol>
	<li>Syms, R. R. A., Yeatman, E. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Self-assembly+of+3-dimensional+microstructures+using+rotation+by+surface-tension+forces.">Self-assembly of 3-dimensional microstructures using rotation by surface-tension forces.</a> Electronics Letters. 29 (8), 662-664 (1993).</li><li>Smela, E., Inganas, O., Lundstrom, I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Controlled+folding+of+micrometer-size+structures.">Controlled folding of micrometer-size structures.</a> Science. 268 (5218), 1735-1738 (1995).</li><li>Ebefors, T., Kalvesten, E., Stemme, G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=New+small+radius+joints+based+on+thermal+shrinkage+of+polyimide+in+V-grooves+for+robust+self-assembly+3D+microstructures.">New small radius joints based on thermal shrinkage of polyimide in V-grooves for robust self-assembly 3D microstructures.</a> Journal of Micromechanics and Microengineering. 8, 188-194 (1998).</li><li>Syms, R. R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Rotational+self-assembly+of+complex+microstructures+by+the+surface+tension+of+glass.">Rotational self-assembly of complex microstructures by the surface tension of glass.</a> Sensors and Actuators A. 65, 238-243 (1998).</li><li>Prinz, V. Y., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Free-standing+and+overgrown+InGaAs/GaAs+nanotubes,+nanohelices+and+their+arrays.">Free-standing and overgrown InGaAs/GaAs nanotubes, nanohelices and their arrays.</a> Physica E. 6, 828-831 (2000).</li><li>Vaccaro, P. O., Kubota, K., Aida, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Strain-driven+self-positioning+of+micromachined+structures.">Strain-driven self-positioning of micromachined structures.</a> Applied Physics Letters. 78 (19), 2852-2854 (2001).</li><li>Schmidt, O. G., Eberl, K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Nanotechnology:+Thin+solid+films+roll+up+into+nanotubes.">Nanotechnology: Thin solid films roll up into nanotubes.</a> Nature. 410, 168 (2001).</li><li>Kladitis, P. E., Linderman, R. J., Bright, V. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Solder+self-assembled+micro+axial+flow+fan+driven+by+a+scratch+drive+actuator+rotary+motor.">Solder self-assembled micro axial flow fan driven by a scratch drive actuator rotary motor.</a> , 598-601 (2001).</li><li>Gracias, D. H., Kavthekar, V., Love, J. C., Paul, K. E., Whitesides, G. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Fabrication+of+micrometer-scale,+patterned+polyhedra+by+self-assembly.">Fabrication of micrometer-scale, patterned polyhedra by self-assembly.</a> Advanced Materials. 14 (3), 235-238 (2002).</li><li>Dahlmann, G. W., Yeatman, E. M., Young, P., Robertson, I. D., Lucyszyn, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Fabrication,+RF+characteristics+and+mechanical+stability+of+self-assembled+3D+microwave+inductors.">Fabrication, RF characteristics and mechanical stability of self-assembled 3D microwave inductors.</a> Sensors and Actuators A. 97-98, 215-220 (2002).</li><li>Patterson, P. R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+scanning+micromirror+with+angular+comb+drive+actuation.">A scanning micromirror with angular comb drive actuation.</a> , 544-547 (2001).</li><li>Syms, R. R. A., Yeatman, E. M., Bright, V. M., Whitesides, G. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Surface+Tension-Powered+Self-Assembly+of+Microstructures-The+State-of-the-Art.">Surface Tension-Powered Self-Assembly of Microstructures-The State-of-the-Art.</a> Journal of Microelectromechanical Systems. 12 (4), 387-417 (2003).</li><li>Kubota, K., Fleischmann, T., Saravanan, S., Vaccaro, P. O., Aida, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Self-assembly+of+microstage+using+micro-origami+technique+on+GaAs.">Self-assembly of microstage using micro-origami technique on GaAs.</a> Japanese Journal of Applied Physics. 42, 4079-4083 (2003).</li><li>Boncheva, M., Whitesides, G. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Templated+self-assembly:+Formation+of+folded+structures+by+relaxation+of+pre-stressed,+planar+tapes.">Templated self-assembly: Formation of folded structures by relaxation of pre-stressed, planar tapes.</a> Advanced Materials. 17 (5), 553-557 (2005).</li><li>Hong, Y. K., Syms, R. R. A., Pister, K. S. J., Zhou, L. X. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Design,+fabrication+and+test+of+self-assembled+optical+corner+cube+reflectors.">Design, fabrication and test of self-assembled optical corner cube reflectors.</a> Journal of Micromechanics and Microengneering. 15, 663-672 (2005).</li><li>Arora, W. J., Nichol, A. J., Smith, H. I., Barbastathis, G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Membrane+folding+to+achieve+three-dimensional+nanostructures:+Nanopatterned+silicon+nitride+folded+with+stressed+chromium+hinges.">Membrane folding to achieve three-dimensional nanostructures: Nanopatterned silicon nitride folded with stressed chromium hinges.</a> Applied Physics Letters. 88, 053108 (2006).</li><li>Leong, T. G., Zarafshar, A. M., Gracias, D. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Three-Dimensional+Fabrication+at+Small+Size+Scales.">Three-Dimensional Fabrication at Small Size Scales.</a> Small. 6 (7), 792-806 (2010).</li><li>Wang, M. -. F., Maleki, T., Ziaie, B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+self-assembled+3D+microelectrode+array.">A self-assembled 3D microelectrode array.</a> Journal of Micromechanics and Microengineering. 20, 035013 (2010).</li><li>Ionov, L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Soft+microorigami:+self-folding+polymer+films.">Soft microorigami: self-folding polymer films.</a> Soft Matter. 7, 6786-6791 (2011).</li><li>Randall, C. L., Gultepe, E., Gracias, D. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Self-folding+devices+and+materials+for+biomedical+applications.">Self-folding devices and materials for biomedical applications.</a> Trends in Biotechnology. 30 (3), 138-146 (2012).</li><li>Gimi, B., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Self-assembled+three+dimensional+radio+frequency+(RF)+shielded+containers+for+cell+encapsulation.">Self-assembled three dimensional radio frequency (RF) shielded containers for cell encapsulation.</a> Biomedical Microdevices. 7 (4), 341-345 (2005).</li><li>Cho, J. H., Azam, A., Gracias, D. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Three+dimensional+nanofabrication+using+surface+forces.">Three dimensional nanofabrication using surface forces.</a> Langmuir. 26 (21), 16534-16539 (2010).</li><li>Pandey, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Algorithmic+design+of+self-folding+polyhedra.">Algorithmic design of self-folding polyhedra.</a> Proceedings of the National Academy of Sciences of the United States of America. 108 (50), 19885-19890 (2011).</li><li>Leong, T. G., Benson, B. R., Call, E. K., Gracias, D. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Thin+film+stress+driven+self-folding+of+microstructured+containers.">Thin film stress driven self-folding of microstructured containers.</a> Small. 4 (10), 1605-1609 (2008).</li><li>Leong, T. G., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Tetherless+thermobiochemically+actuated+microgrippers.">Tetherless thermobiochemically actuated microgrippers.</a> Proceedings of the National Academy of Sciences of the United States of America. 106 (3), 703-708 (2009).</li><li>Cho, J. H., Gracias, D. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Self-assembly+of+lithographically+patterned+nanoparticles.">Self-assembly of lithographically patterned nanoparticles.</a> Nano Letters. 9 (12), 4049-4052 (2009).</li><li>Azam, A., Laflin, K., Jamal, M., Fernandes, R., Gracias, D. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Self-folding+micropatterned+polymeric+containers.">Self-folding micropatterned polymeric containers.</a> Biomedical Microdevices. 13 (1), 51-58 (2011).</li><li>Azam, A., Leong, T. G., Zarafshar, A. M., Gracias, D. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Compactness+determines+the+success+of+cube+and+octahedron+self-assembly.">Compactness determines the success of cube and octahedron self-assembly.</a> PLoS One. 4 (2), e4451 (2009).</li><li>Harsh, K., Lee, Y. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Modeling+for+solder+self-assembled+MEMS.">Modeling for solder self-assembled MEMS.</a> Proceedings of SPIE. 3289, 177-184 (1998).</li><li>Syms, R. R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Equilibrium+of+hinged+and+hingeless+structures+rotated+using+surface+tension+forces.">Equilibrium of hinged and hingeless structures rotated using surface tension forces.</a> Journal of Microelectromechanical Systems. 4 (4), 177-184 (1995).</li><li>Leong, T. G., Lester, P. A., Koh, T. L., Call, E. K., Gracias, D. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Surface+tension-driven+self-folding+polyhedra.">Surface tension-driven self-folding polyhedra.</a> Langmuir. 23, 8747-8751 (2007).</li><li>Harsh, K. F., Bright, V. M., Lee, Y. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Solder+self-assembly+for+three-dimensional+microelectromechanical+systems.">Solder self-assembly for three-dimensional microelectromechanical systems.</a> Sensors and Actuators A. 77, 237-244 (1999).</li><li>Nikishkov, G. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Curvature+estimation+for+multilayer+hinged+structures+with+initial+strains.">Curvature estimation for multilayer hinged structures with initial strains.</a> Journal of Applied Physics. 94 (8), 5333-5336 (2003).</li><li>He, H. Y., Guan, J. J., Lee, J. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=An+oral+delivery+device+based+on+self-folding+hydrogels.">An oral delivery device based on self-folding hydrogels.</a> Journal of Controlled Release. 110 (2), 339-346 (2006).</li><li>Luchnikov, V., Sydorenko, O., Stamm, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Self-rolled+polymer+and+composite+polymer/metal+micro-+and+nanotubes+with+patterned+inner+walls.">Self-rolled polymer and composite polymer/metal micro- and nanotubes with patterned inner walls.</a> Advanced Materials. 17, 1177-1182 (2005).</li><li>Bassik, N., Abebe, B. T., Laflin, K. E., Gracias, D. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Photolithographically+patterned+smart+hydrogel+based+bilayer+actuators.">Photolithographically patterned smart hydrogel based bilayer actuators.</a> Polymer. 51 (26), 6093-6098 (2010).</li><li>Jamal, M., Zarafshar, A. M., Gracias, D. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Differentially+photo-crosslinked+polymers+enable+self-assembling+microfluidics.">Differentially photo-crosslinked polymers enable self-assembling microfluidics.</a> Nature Communications. 2 (527), 1-6 (2011).</li><li>Harazim, S. M., Xi, W., Schmidt, C. K., Sanchez, S., Schmidt, O. G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Fabrication+and+applications+of+large+arrays+of+multifunctional+rolled-up+SiO/SiO2+microtubes.">Fabrication and applications of large arrays of multifunctional rolled-up SiO/SiO2 microtubes.</a> Journal of Materials Chemistry. 22, 2878-2884 (2012).</li><li>Randall, C. L., Kalinin, Y. V., Jamal, M., Shah, A., Gracias, D. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Self-folding+immunoprotective+cell+encapsulation+devices.">Self-folding immunoprotective cell encapsulation devices.</a> Nanomedicine. 7 (6), 686-689 (2011).</li><li>Kalinin, Y. V., Randhawa, J. S., Gracias, D. 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관심 없음 충돌이 선언 없습니다.

우리의 종이 접기에서 영감을 조립 과정은 다양한 있으며, 자료, 모양과 크기의 다양한 범위의 3D 정적 및 재구성 입자의 다양한 합성에 사용될 수 있습니다. 또한,이 입자에 정확하게 패턴 센서와 전자 모듈의 기능은 광학 및 전자 중요합니다. 패턴이 상대적으로 부정확 한 아르 다른 방법에 의해 형성 누덕 누덕 기운 입자는 대조적으로,이 방법은 정확하게 패턴 입자를 합성 할 수있는 방법을 제공합니다. 표면 장력 기반의 조립에서 밀봉 경첩을 액화의 사용은 입자 (냉각)에 잘 밀봉 및 조립 후 기계적 강성 할 수 있도록합니다. 이전, 우리는 시임에도 작은 분자 39,40에 새지 것을 관찰했다. 조립 후 끊을의 얇은 층의 전착 추가 강도를 제공하고 솔기의 누출 방지 자연을 향상시킬 수 있습니다. 박막 스트레스를 기반 접이식 응용 프로그램에 유용합니다 어떤 세인트imuli 대응 접이식은 이러한 체외과 생체 생물 샘플링과 로봇의 픽업 및 장소 작업에서 수행하는 데 사용 된 microgrippers에서와 같이 필요합니다. 여기에 설명 된 특정 방법은 한 번만 닫 재구성 microgrippers을 만드는 데 사용할 수 있지만, 자료 및 bilayers에 스트레스를 조작하는 방법의 적절한 선택도 여러 사이클 37, 41으로 재구성 할 수 있습니다 붙잡는 장치를 만들 이용 될 수있다. 전원 장치를에 잔류 응력의 사용의 하이라이트는 어떤 tethers 또는 전선을 필요로하므로 장소에 도달하기 위해 최선의 작동을 사용하려면 우수한 기동성을 가지고 있지 않다는 것입니다. 또한, 고분자 트리거의 적절한 선택에 의해 자극 반응 행동은 로봇과 수술에 대한 관련성이 자율적 기능을 활성화하는 효소 42를 포함 자극의 범위를 사용할 수 있습니다.

<table border="1"><tbody><tr><td> 시약의 이름 </td><td> 회사 </td><td> 카탈로그 번호 </td><td> 코멘트 </td></tr><tr><td> 950 폴리 메틸 메타 크릴 레이트의 A11 </td><td> 마이크로 화학 </td><td> M230011 </td><td> 희생 층 </td></tr><tr><td> 크롬 도금 텅스텐 막대 </td><td> RD 매티스 회사 </td><td> CRW-2 </td><td> 크롬에 대한 증발 소스 </td></tr><tr><td> 구리 총알 </td><td> 알파 Aesar </td><td> 7440-50-8 </td><td> 잘라 내기위한 증발 소스 </td></tr><tr><td> 골드 슬러그 </td><td> 알파 Aesar </td><td> 7440-57-5 </td><td> 끊을에 증발 소스 </td></tr><tr><td> SPR 220 7.0 </td><td> Rohm와 하스 </td><td> 10016640 </td><td> 긍정적 인 포토 레지스트 </td></tr><tr><td> S 1800 시리즈는 photoresists </td><td> Rohm와 Hass </td><td></td><td> 긍정적 인 Photoresist </td></tr><tr><td> Megaposit MF-26 개발 </td><td> Rohm와 하스 </td><td> 10016574 </td><td> SPR 220 7.0 포토 레지스트에 대한 개발자 </td></tr><tr><td> Microposit 351 개발자 </td><td> Rohm와 Hass </td><td> 10016653 </td><td> S 1800 시리즈 개발자 photoresists </td></tr><tr><td> 니켈 Sulfamate </td><td> 기술 주식회사 </td><td> 030175 </td><td> 니켈 도금을위한 솔루션 </td></tr><tr><td> Techni 솔더 메이트 NF 820 40분의 60 RTU </td><td> 기술 주식회사 </td><td> 330681 </td><td> PB-SN 경첩을위한 도금 솔루션 </td></tr><tr><td> APS 100 구리 에칭 제 </td><td> Transene 회사 주식회사 </td><td> 021221 </td><td> 구리 에칭 </td></tr><tr><td> CRE 473 크롬 에칭 제 </td><td> Transene 회사 주식회사 </td><td> 040901 </td><td> 크롬 에칭 </td></tr><tr><td> 1-메틸-2-Pyrollidinone (NMP) </td><td> 시그마 - 알드리치 </td><td> 엠79,603 </td><td> 자기 접이식 기반 PB-SN의 경첩에 대한 높은 비등점 유기 용매 </td></tr><tr><td> Indalloy 5RMA 자속 </td><td> 미국의 인듐 공사 </td><td> FL28372 </td><td> 땜납 표면을 청소하고 좋은 PB-SN 리플 로우를 위해 산화를 억제하는 화학 </td></tr></tbody></table>

origami inspired self-assembly of patterned and reconfigurable particles

이러한 석판 술, 전자 - 빔 리소그래피와 정확하게 패턴을 2 차원 (2D) 구조를하는 데 사용할 수있는 소프트 리소그래피와 같은 많은 기술이 있습니다. 이러한 기술은, 성숙 높은 정밀도를 제공하고 있으며, 그 중 많은 사람들이 높은 처리량 방식으로 구현 될 수있다. 우리는 평면 리소그래피의 장점을 활용하고 표면 장력이나 잔류 응력에서 파생 1-20 항에있어서, 물리적 힘이 세 차원 (3D) 구조로 곡선 또는 배 평면 구조에 사용되는 자기 접는 방법과 함께 조화를 이루고 있습니다. 그렇게, 우리는 대량 정확하게 합성 도전 정적 및 재구성 입자를 패턴 생산이 가능합니다. 이 논문에서, 우리는 세부, 특히, 패턴 입자를 만드는 실험 프로토콜을 시각화 (가) 영구적으로 보세, 중공, polyhedra 그 자체 조립 및 액화 경첩 21-23의 표면 에너지의 최소화로 인해 자기 인감및 (b) grippers 그 자체 배 잔류 응력 전원이 공급되는 경첩 24,25 때문입니다. 설명 특정 프로토콜은 마이크로 미터에서 센티미터 길이의 비늘에 이르기까지 전체 크기로 입자를 생성하는 데 사용할 수 있습니다. 또한, 임의의 패턴은 콜로이드 과학, 전자, 광학, 의학의 중요성 입자의 표면에 정의 할 수 있습니다. 더 일반적으로, 자기 밀폐 경첩과 자기 조립 기계 강성 입자의 개념은 더 작은에서 입자의 생성에 어떤 프로세스 수정,, 100 nm의 길이의 비늘 22, 26과 및 금속 21 등의 재료의 범위, 적용 , 반도체 9 폴리머 27. 재구성 붙잡는 장치의 잔류 응력 전원 작동과 관련하여, 우리의 특정 프로토콜은 100 μm에서 2.5 mm에 이르기까지 다양한 크기로 장치에 관련성 크롬 경첩을 활용합니다. 그러나, 더 일반적으로, 이러한 테 더링이없는 잔류 응력의 개념전원 작동 가능성이 더 작은 nanoscale 붙잡는 장치를 만드는 데 이러한 heteroepitaxially 입금 반도체 필름 5,7 등 다른 스트레스가 높은 재료와 함께 사용할 수 있습니다.

Watch this Scientific Journal Video about Origami Inspired Self-assembly of Patterned and Reconfigurable Particles at JoVE.com

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

우리는 2 차원 (2D) 전구체의 패턴과 재구성 입자의 합성 실험 내용을 설명합니다. 이 방법론은 polyhedra과 마이크로에서 센티미터 규모에 이르기까지 다양한 길이의 비늘에서 붙잡는 장치를 포함하여 모양의 다양한 입자를 생성하는 데 사용할 수 있습니다.

종이 접기 고취 패턴 및 재구성 입자의 자기 조립

There are numerous techniques such as photolithography, electron-beam lithography and soft-lithography that can be used to precisely pattern two ...

origami-inspired-self-assembly-patterned-reconfigurable

Research

JoVE Journal

Chemistry

21.5K 조회수.  The Johns Hopkins University. 우리는 2 차원 (2D) 전구체의 패턴과 재구성 입자의 합성 실험 내용을 설명합니다. 이 방법론은 polyhedra과 마이크로에서 센티미터 규모에 이르기까지 다양한 길이의 비늘에서 붙잡는 장치를 포함하여 모양의 다양한 입자를 생성하는 데 사용할 수 있습니다.

비디오: Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

In nature, complex functional structures are formed by the self-assembly of biomolecules under mild conditions. Understanding the forces that control self-assembly and mimicking this process in vitro will bring about major advances in the areas of materials science and nanotechnology. Among the available biological building blocks, peptides have several advantages as they present substantial diversity, their synthesis in large scale is straightforward, and they can easily be modified with biological and chemical entities1,2. Several classes of designed peptides such as cyclic peptides, amphiphile peptides and peptide-conjugates self-assemble into ordered structures in solution. Homoaromatic dipeptides, are a class of short self-assembled peptides that contain all the molecular information needed to form ordered structures such as nanotubes, spheres and fibrils3-8. A large variety of these peptides is commercially available.
This paper presents a procedure that leads to the formation of ordered structures by the self-assembly of homoaromatic peptides. The protocol requires only commercial reagents and basic laboratory equipment. In addition, the paper describes some of the methods available for the characterization of peptide-based assemblies. These methods include electron and atomic force microscopy and Fourier-Transform Infrared Spectroscopy (FT-IR). Moreover, the manuscript demonstrates the blending of peptides (coassembly) and the formation of a &#34;beads on a string&#34;-like structure by this process.9 The protocols presented here can be adapted to other classes of peptides or biological building blocks and can potentially lead to the discovery of new peptide-based structures and to better control of their assembly.

This paper describes the formation of highly ordered peptide-based structures by the spontaneous process of self-assembly. The method utilizes commercially available peptides and common lab equipment. This technique can be applied to a large variety of peptides and may lead to the discovery of new peptide-based assemblies.

짧은 펩타이드의 자기 조립에 의해 주문 생체 고분자 구조의 형성

In nature, complex functional structures are formed by the self-assembly of biomolecules under mild conditions. Understanding the forces that control ...

연구

화학

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Current methods in DNA nano-architecture have successfully engineered a variety of 2D and 3D structures using principles of self-assembly. In this article, we describe detailed protocols on how to fabricate sophisticated 2D shapes through the self-assembly of uniquely addressable single-stranded DNA tiles which act as molecular pixels on a molecular canvas. Each single-stranded tile (SST) is a 42-nucleotide DNA strand composed of four concatenated modular domains which bind to four neighbors during self-assembly. The molecular canvas is a rectangle structure self-assembled from SSTs. A prescribed complex 2D shape is formed by selecting the constituent molecular pixels (SSTs) from a 310-pixel molecular canvas and then subjecting the corresponding strands to one-pot annealing. Due to the modular nature of the SST approach we demonstrate the scalability, versatility and robustness of this method. Compared with alternative methods, the SST method enables a wider selection of information polymers and sequences through the use of de novo designed and synthesized short DNA strands.

DNA tiling is an effective approach to make programmable nanostructures. We describe the protocols to construct complex two-dimensional shapes by the self-assembly of single-stranded DNA tiles.

단일 가닥 DNA 타일에서 단지 두 차원 모양의 자기 조립 (self-assembly)

Current methods in DNA nano-architecture have successfully engineered a variety of 2D and 3D structures using principles of self-assembly. In this ...

Preparation of Mica and Silicon Substrates for DNA Origami Analysis and Experimentation

The designed nature and controlled, one-pot synthesis of DNA origami provides exciting opportunities in many fields, particularly nanoelectronics. Many of these applications require interaction with and adhesion of DNA nanostructures to a substrate. Due to its atomically flat and easily cleaned nature, mica has been the substrate of choice for DNA origami experiments. However, the practical applications of mica are relatively limited compared to those of semiconductor substrates. For this reason, a straightforward, stable, and repeatable process for DNA origami adhesion on derivatized silicon oxide is presented here. To promote the adhesion of DNA nanostructures to silicon oxide surface, a self-assembled monolayer of 3-aminopropyltriethoxysilane (APTES) is deposited from an aqueous solution that is compatible with many photoresists. The substrate must be cleaned of all organic and metal contaminants using Radio Corporation of America (RCA) cleaning processes and the native oxide layer must be etched to ensure a flat, functionalizable surface. Cleanrooms are equipped with facilities for silicon cleaning, however many components of DNA origami buffers and solutions are often not allowed in them due to contamination concerns. This manuscript describes the set-up and protocol for in-lab, small-scale silicon cleaning for researchers who do not have access to a cleanroom or would like to incorporate processes that could cause contamination of a cleanroom CMOS clean bench. Additionally, variables for regulating coverage are discussed and how to recognize and avoid common sample preparation problems is described.

Reproducible cleaning processes for substrates used in DNA origami research are described, including bench-top RCA cleaning and derivatization of silicon oxide. Protocols for surface preparation, DNA origami deposition, drying parameters, and simple experimental set-ups are illustrated.

DNA 종이 접기 분석 및 실험에 대한 운모와 실리콘 기판의 제조

The designed nature and controlled, one-pot synthesis of DNA origami provides exciting opportunities in many fields, particularly nanoelectronics. Many of ...

Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness

We demonstrate a straightforward protocol to graft pristine multiwalled carbon nanotubes (MWCNTs) with polystyrene (PS) chains at the sidewalls through a free-radical polymerization strategy to enable the modulation of the nanotube surface properties and produce supramolecular self-assembly of the nanostructures. First, a selective hydroxylation of the pristine nanotubes through a biphasic catalytically mediated oxidation reaction creates superficially distributed reactive sites at the sidewalls. The latter reactive sites are subsequently modified with methacrylic moieties using a silylated methacrylic precursor to create polymerizable sites. Those polymerizable groups can address further polymerization of styrene to produce a hybrid nanomaterial containing PS chains grafted to the nanotube sidewalls. The polymer-graft content, amount of silylated methacrylic moieties introduced and hydroxylation modification of the nanotubes are identified and quantified by Thermogravimetric Analysis (TGA). The presence of reactive functional groups hydroxyl and silylated methacrylate are confirmed by Fourier Transform Infrared Spectroscopy (FT-IR). Polystyrene-grafted carbon nanotube solutions in tetrahydrofuran (THF) provide wall-to-wall collinearly self-assembled nanotubes when cast samples are analyzed by transmission electron microscopy (TEM). Those self-assemblies are not obtained when suitable blanks are similarly cast from analogous solutions containing non-grafted counterparts. Therefore, this method enables the modification of the nanotube anisotropic patchiness at the sidewalls which results into spontaneous auto-organization at the nanoscale.

A procedure for the synthesis of polystyrene-grafted multiwalled carbon nanotubes using successive chemical modification steps to selectively introduce the polymer chains to the sidewalls and their self-assembly via anisotropic patchiness is presented.

자기 집합에 있도록 폴리스 티 렌과 이방성 Patchiness Multiwalled 탄소 나노튜브를 접목

We demonstrate a straightforward protocol to graft pristine multiwalled carbon nanotubes (MWCNTs) with polystyrene (PS) chains at the sidewalls through a ...

Liquid-cell Transmission Electron Microscopy for Tracking Self-assembly of Nanoparticles

Drying a nanoparticle dispersion is a versatile way to create self-assembled structures of nanoparticles, but the mechanism of this process is not fully understood. We have traced the trajectories of individual nanoparticles using liquid-cell transmission electron microscopy (TEM) to investigate the mechanism of the assembly process. Herein, we present the protocols used for liquid-cell TEM studies of the self-assembly mechanism. First, we introduce the detailed synthetic protocols used to produce uniformly sized platinum and lead selenide nanoparticles. Next, we present the microfabrication processes used to produce liquid cells with silicon nitride or silicon windows and then describe the loading and imaging procedures of the liquid-cell TEM technique. Several notes are included to provide helpful tips for the entire process, including how to manage the fragile cell windows. The individual motions of nanoparticles tracked by liquid-cell TEM revealed that changes in the solvent boundaries caused by evaporation affected the self-assembly process of nanoparticles. The solvent boundaries drove nanoparticles to primarily form amorphous aggregates, followed by flattening of the aggregates to produce a 2-dimensional (2D) self-assembled structure. These behaviors are also observed for different nanoparticle types and different liquid-cell compositions.

Here we introduce experimental protocols for the real-time observation of a self-assembly process using liquid-cell transmission electron microscopy.

나노 입자의 자기 조립 추적에 대 한 액체 셀 전송 전자 현미경 검사 법

Drying a nanoparticle dispersion is a versatile way to create self-assembled structures of nanoparticles, but the mechanism of this process is not fully ...

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control

Micellar nanocrystals (micelles with encapsulated nanocrystals) have become an emerging major class of nanobiomaterials. We describe a method of fabricating micellar nanocrystals based on combining top-down electrospray, bottom-up self-assembly, and solvent-based structure control. This method involves first using electrospray to generate uniform ultrafine liquid droplets, each of which functions as a micro-reactor in which self-assembly reaction occurs forming micellar nanocrystals, with the structures (micelle shape and nanocrystal encapsulation) controlled by the organic solvent used. This method is largely continuous and produces high quality micellar nanocrystal products with an inexpensive structure control approach. By using a water-miscible organic solvent tetrahydrofuran (THF), worm-shaped micellar nanocrystals can be produced due to solvent-induced/facilitated micelle fusion. Compared with the common spherical micellar nanocrystals, worm-shaped micellar nanocrystals can offer minimized non-specific cellular uptake, thus enhancing biological targeting. By co-encapsulating multiple nanocrystals into each micelle, multifunctional or synergistic effects can be achieved. Current limitations of this fabrication method, which will be part of the future work, primarily include imperfect encapsulation in the micellar nanocrystal product and the incompletely continuous nature of the process.

The present work describes a method to fabricate micellar nanocrystals, an emerging major class of nanobiomaterials. This method combines top-down electrospray, bottom-up self-assembly, and solvent-based structure control. The fabrication method is largely continuous, can produce high quality products, and possesses an inexpensive means of structure control.

구형 및 벌레 모양의 Micellar 나노 자기 조립, 분무, 결합 하 여 용 매 기반 구조 제어의 제조

Micellar nanocrystals (micelles with encapsulated nanocrystals) have become an emerging major class of nanobiomaterials. We describe a method of ...

Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles

Surface functionalization of nanodiamonds (NDs) is still challenging due to the diversity of functional groups on the ND surfaces. Here, we demonstrate a simple protocol for the multifunctional surface modification of NDs by using mussel-inspired polydopamine (PDA) coating. In addition, the functional layer of PDA on NDs could serve as a reducing agent to synthesize and stabilize metal nanoparticles. Dopamine (DA) can self-polymerize and spontaneously form PDA layers on ND surfaces if the NDs and dopamine are simply mixed together. The thickness of a PDA layer is controlled by varying the concentration of DA. A typical result shows that a thickness of ~5 to ~15 nm of the PDA layer can be reached by adding 50 to 100 &#181;g/mL of DA to 100 nm ND suspensions. Furthermore, the PDA-NDs are used as a substrate to reduce metal ions, such as Ag[(NH3)2]+, to silver nanoparticles (AgNPs). The sizes of the AgNPs rely on the initial concentrations of Ag[(NH3)2]+. Along with an increase in the concentration of Ag[(NH3)2]+, the number of NPs increases, as well as the diameters of the NPs. In summary, this study not only presents a facile method for modifying the surfaces of NDs with PDA, but also demonstrates the enhanced functionality of NDs by anchoring various species of interest (such as AgNPs) for advanced applications.

A facile protocol is presented to functionalize the surfaces of nanodiamonds with polydopamine.

Nanodiamonds 및은 나노 입자의 그것의 감소의 바이오 영감 Polydopamine 표면 수정

Surface functionalization of nanodiamonds (NDs) is still challenging due to the diversity of functional groups on the ND surfaces. Here, we demonstrate a ...

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

DNA origami nanostructures hold an immense potential to be used for biological and medical applications. However, low-salt conditions and nucleases in physiological fluids induce denaturation and degradation of self-assembled DNA nanostructures. In non-viral gene delivery, enzymatic degradation of DNA is overcome by the encapsulation of the negatively charged DNA in a cationic shell. Herein, inspired by gene delivery advancements, a simple, one-step and robust methodology is presented for the stabilization of DNA origami nanostructures by coating them with chitosan and linear polyethyleneimine. The polycation coating efficiently protects DNA origami nanostructures in Mg-depleted and nuclease-rich media. This method also preserves the full addressability of enzyme- and aptamer-based functionalization of DNA nanostructures.

Here, a protocol for the protection of DNA origami nanostructures in Mg-depleted and nuclease-rich media using natural cationic polysaccharide chitosan and synthetic linear polyethyleneimine (LPEI) coatings is presented.

유전자 치료 DNA 종이 접기 Nanostructures의 보호를 위한 Polycation 코팅을 영감

DNA origami nanostructures hold an immense potential to be used for biological and medical applications. However, low-salt conditions and nucleases in ...

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

The production of monodisperse cylindrical micelles is a significant challenge in polymer chemistry. Most cylindrical constructs formed from diblock copolymers are produced by one of three techniques: thin film rehydration, solvent switching or polymerization-induced self-assembly, and produce only flexible, polydisperse cylinders. Crystallization-driven self-assembly (CDSA) is a method which can produce cylinders with these properties, by stabilizing structures of a lower curvature due to the formation of a crystalline core. However, the living polymerization techniques by which most core-forming blocks are formed are not trivial processes and the CDSA process may yield unsatisfactory results if carried out incorrectly. Here, the synthesis of cylindrical nanoparticles from simple reagents is shown. The drying and purification of reagents prior to a ring-opening polymerization of &#949;-caprolactone catalyzed by diphenyl phosphate is described. This polymer is then chain extended by methyl methacrylate (MMA) followed by N,N-dimethyl acrylamide (DMA) using reversible addition&#8722;fragmentation chain-transfer (RAFT) polymerization, affording a triblock copolymer that can undergo CDSA in ethanol. The living CDSA process is outlined, the results of which yield cylindrical nanoparticles up to 500 nm in length and a length dispersity as low as 1.05. It is anticipated that these protocols will allow others to produce cylindrical nanostructures and elevate the field of CDSA in the future.

Crystallization-driven self-assembly (CDSA) displays the unique ability to fabricate cylindrical nanostructures of narrow length distributions. The organocatalyzed ring-opening polymerization of &#949;-caprolactone and subsequent chain extensions of methyl methacrylate and N,N-dimethyl acrylamide are demonstrated. A living CDSA protocol that produces monodisperse cylinders up to 500 nm in length is outlined.

생분해성 블록 공합체의 결정화 구동 자가 조립을 통해 단분산 원통형 나노 입자의 합성

The production of monodisperse cylindrical micelles is a significant challenge in polymer chemistry. Most cylindrical constructs formed from diblock ...

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Structural DNA nanotechnology provides a viable route for building from the bottom-up using DNA as construction material. The most common DNA nanofabrication technique is called DNA origami, and it allows high-throughput synthesis of accurate and highly versatile structures with nanometer-level precision. Here, it is shown how the spatial information of DNA origami can be transferred to metallic nanostructures by combining the bottom-up DNA origami with the conventionally used top-down lithography approaches. This allows fabrication of billions of tiny nanostructures in one step onto selected substrates. The method is demonstrated using bowtie DNA origami to create metallic bowtie-shaped antenna structures on silicon nitride or sapphire substrates. The method relies on the selective growth of a silicon oxide layer on top of the origami deposition substrate, thus resulting in a patterning mask for following lithographic steps. These nanostructure-equipped surfaces can be further used as molecular sensors (e.g., surface-enhanced Raman spectroscopy (SERS)) and in various other optical applications at the visible wavelength range owing to the small feature sizes (sub-10 nm). The technique can be extended to other materials through methodological modifications; therefore, the resulting optically active surfaces may find use in development of metamaterials and metasurfaces.

Here, we describe a protocol to create discrete and accurate inorganic nanostructures on substrates using DNA origami shapes as guiding templates. The method is demonstrated by creating plasmonic gold bowtie-shaped antennas on a transparent substrate (sapphire).