Stereotactic Injection of rAAV-α-SYN into the Rat Substantia Nigra
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Results: Neurodegeneration Induced by rAAV2/7 α-SYN
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Conclusion
필기록
The overall goal of this procedure is to develop a viral vector based animal model for Parkinson's Disease via Stereotactic Injection in the central nervous system. This method can be used to develop normal animal models which allow for pre-clinic
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This manuscript describes how viral vector-mediated local gene delivery provides an attractive way to express transgenes in the central nervous system. The protocol outlines all crucial steps to perform a viral vector injection in the substantia nigra of the rat to develop a viral vector-based animal model for Parkinson's disease.