Injurious Ventilation with High Tidal Volume/Low PEEP (High Tv/low PEEP)
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Results: Effects of the Injurious Ventilation on the Lungs
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Conclusion
필기록
The combination of surfactant wash-out with injurious ventilation reduces the recruitability of the lung injury as compared to models with exclusive surfactant wash-out. The model is reproducible and does not require additional techniques. Further
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A combination of surfactant washout using 0.9% saline (35 mL/kg body weight, 37 °C) and high tidal volume ventilation with low PEEP to cause moderate ventilator induced lung injury (VILI) results in experimental acute respiratory distress syndrome (ARDS). This method provides a model of lung injury with low/limited recruitability to study the effect of various ventilation strategies for extended periods.