Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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10:44 min
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May 15th, 2019
DOI :
May 15th, 2019
•Rozdziały w tym wideo
0:04
Title
0:52
Preparation of Proteolysis-targeting Chimera (PROTAC) Homodimer 8 (Compound 8)
4:32
Preparation of tert-Butyl N-(1-Methyl-2,6-dioxo-3-piperidyl)carbamate (Building Block 2 for Heterodimer 9)
5:52
Functional Validation of PROTAC Compounds
8:12
Results: Characterization and Efficacy of PROTACs
9:52
Conclusion
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