A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

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5.3K Views

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07:17 min

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January 29th, 2021

DOI :

10.3791/62033-v

January 29th, 2021

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Vincent Law¹^,², Margi Baldwin³, Ganesan Ramamoorthi⁴, Krithika Kodumudi⁴, Nam Tran¹, Inna Smalley⁵, Derek Duckett⁶, Pawel Kalinski⁷, Brian Czerniecki⁴, Keiran S. M. Smalley², Peter A. Forsyth¹^,²

¹Department of Neuro-Oncology, H. Lee Moffitt Cancer Center & Research Institute, ²Department of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, ³Department of Comparative Medicine, University of South Florida, ⁴Department of Breast Oncology, H. Lee Moffitt Cancer Center & Research Institute, ⁵Department of Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute, ⁶Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, ⁷Department of Medical Oncology, Roswell Park Comprehensive Cancer Center

Podsumowanie

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Murine Ommaya Model

Leptomeningeal Disease

Targeted Therapy

Cerebrospinal Fluid Delivery

Central Nervous System Metastases

University Of South Florida

Buprenorphine Injection

Stereotactic Surgery

Surgical Technique

Cell Suspension Injection

Rozdziały w tym wideo

0:04

Introduction

1:07

Injection of CTCs into CSF to Generate a Mouse LMD Model

3:37

Murine Ommaya Assembly and Implantation

5:20

Results: Direct-Targeted Immunotherapy Using the Murine Ommaya Increases the Overall Survival of Breast Cancer-Associated Leptomeningeal Disease Mice

6:37

Conclusion

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