Lombardi Comprehensive Cancer Center,
Department of Oncology,
Lombardi Comprehensive Cancer Center, Department of Oncology,
Department of Oncology, Lombardi Comprehensive Cancer Center
I am a tenured Professor and Associate Director for Basic Research at the Lombardi Comprehensive Cancer Center, Georgetown University. I trained as an MD/PhD at the Gutenberg University in Mainz and Goethe Uiversity in Frankfurt, Germany joined NIH USA to study growth factor signaling. I was recruited to Georgetown University Medical School where I run a research lab and teach in the Medical and Graduate School. My research has focused on tumor / stromal interaction with a particular emphasis on invasion and metastasis, crosstalk with the immune system and uncovering driver pathways suitable for drug targeting.
Distinct Response of Circulating microRNAs to the Treatment of Pancreatic Cancer Xenografts with FGFR and ALK Kinase Inhibitors.
Cancers Mar, 2022 | Pubmed ID: 35326668
Melanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophin.
Proceedings of the National Academy of Sciences of the United States of America Dec, 1996 | Pubmed ID: 8962127
Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus.
Proceedings of the National Academy of Sciences of the United States of America Dec, 1996 | Pubmed ID: 8962128
Structure and phylogenetic analysis of an endogenous retrovirus inserted into the human growth factor gene pleiotrophin.
Journal of virology Jul, 1998 | Pubmed ID: 9621070
Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth.
The Journal of biological chemistry Apr, 2002 | Pubmed ID: 11809760
Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development.
Histochemistry and cell biology Jan, 2002 | Pubmed ID: 11819092
Significance of the expression of the growth factor pleiotrophin in pancreatic cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research Mar, 2002 | Pubmed ID: 11895915
Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.
The Journal of biological chemistry Sep, 2002 | Pubmed ID: 12107166
Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.
The Journal of biological chemistry Sep, 2002 | Pubmed ID: 12122009
A role for TGF-beta in estrogen and retinoid mediated regulation of the nuclear receptor coactivator AIB1 in MCF-7 breast cancer cells.
Oncogene Oct, 2002 | Pubmed ID: 12370804
Estradiol rapidly activates Akt via the ErbB2 signaling pathway.
Molecular endocrinology (Baltimore, Md.) May, 2003 | Pubmed ID: 12554767
Complex regulation of the fibroblast growth factor-binding protein in MDA- MB-468 breast cancer cells by CCAAT/enhancer-binding protein beta.
Cancer research Apr, 2003 | Pubmed ID: 12670924
Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway.
Oncogene Apr, 2003 | Pubmed ID: 12687010
Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway.
Oncogene Sep, 2003 | Pubmed ID: 12970748
Up-regulation of fibroblast growth factor-binding protein, by beta-catenin during colon carcinogenesis.
Cancer research Dec, 2003 | Pubmed ID: 14678957
Impact of the nuclear receptor coactivator AIB1 isoform AIB1-Delta3 on estrogenic ligands with different intrinsic activity.
Oncogene Jan, 2004 | Pubmed ID: 14691461
Systemic morphine administration suppresses genes involved in antigen presentation.
Molecular pharmacology Feb, 2004 | Pubmed ID: 14742686
Altered Rho GTPase signaling pathways in breast cancer cells.
Breast cancer research and treatment Mar, 2004 | Pubmed ID: 14999153
Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research Sep, 2004 | Pubmed ID: 15448000
Differential regulation of a fibroblast growth factor-binding protein during skin carcinogenesis and wound healing.
Neoplasia (New York, N.Y.) Sep-Oct, 2004 | Pubmed ID: 15548369
The nuclear receptor coactivator AIB1 mediates insulin-like growth factor I-induced phenotypic changes in human breast cancer cells.
Cancer research Nov, 2004 | Pubmed ID: 15548698
Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway.
Oncogene Mar, 2005 | Pubmed ID: 15759010
Vascular leakage in chick embryos after expression of a secreted binding protein for fibroblast growth factors.
Laboratory investigation; a journal of technical methods and pathology Jun, 2005 | Pubmed ID: 15806140
Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display.
The Journal of biological chemistry Jan, 2006 | Pubmed ID: 16257968
Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome.
American journal of physiology. Regulatory, integrative and comparative physiology Jan, 2006 | Pubmed ID: 16352855
RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response.
Hypertension Feb, 2006 | Pubmed ID: 16391171
Expression of a fibroblast growth factor-binding protein during the development of adenocarcinoma of the pancreas and colon.
Cancer research Jan, 2006 | Pubmed ID: 16424058
Expression analysis of mRNA in formalin-fixed, paraffin-embedded archival tissues by mRNA in situ hybridization.
Methods (San Diego, Calif.) Apr, 2006 | Pubmed ID: 16513366
E6AP mediates regulated proteasomal degradation of the nuclear receptor coactivator amplified in breast cancer 1 in immortalized cells.
Cancer research Sep, 2006 | Pubmed ID: 16951183
The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma.
Seminars in oncology Dec, 2006 | Pubmed ID: 17178288
Effects on neurite outgrowth and cell survival of a secreted fibroblast growth factor binding protein upregulated during spinal cord injury.
American journal of physiology. Regulatory, integrative and comparative physiology Aug, 2007 | Pubmed ID: 17553847
Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1.
Cancer research Aug, 2007 | Pubmed ID: 17671194
The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice.
Cancer research May, 2008 | Pubmed ID: 18483252
Effect of FGF-binding protein 3 on vascular permeability.
The Journal of biological chemistry Oct, 2008 | Pubmed ID: 18669637
Chronic antidepressant treatments increase basic fibroblast growth factor and fibroblast growth factor-binding protein in neurons.
Neuropharmacology Dec, 2008 | Pubmed ID: 18682257
Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells.
Molecular and cellular biology Nov, 2008 | Pubmed ID: 18765637
The role and regulation of the nuclear receptor co-activator AIB1 in breast cancer.
Breast cancer research and treatment Jul, 2009 | Pubmed ID: 19418218
A distinct role for secreted fibroblast growth factor-binding proteins in development.
Proceedings of the National Academy of Sciences of the United States of America May, 2009 | Pubmed ID: 19433791
Tumor angiogenesis: initiation and targeting - therapeutic targeting of an FGF-binding protein, an angiogenic switch molecule, and indicator of early stages of gastrointestinal adenocarcinomas -.
Cancer research and treatment : official journal of Korean Cancer Association Dec, 2006 | Pubmed ID: 19771241
Omics-based molecular target and biomarker identification.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21370102
Hunting ALK to feed targeted cancer therapy.
Nature medicine Mar, 2011 | Pubmed ID: 21383740
Role of the nuclear receptor coactivator AIB1-Delta4 splice variant in the control of gene transcription.
The Journal of biological chemistry Jul, 2011 | Pubmed ID: 21636853
Proteomic analysis of pathways involved in estrogen-induced growth and apoptosis of breast cancer cells.
PloS one , 2011 | Pubmed ID: 21738574
Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancer.
PloS one , 2011 | Pubmed ID: 21738581
Superoxide modulates myogenic contractions of mouse afferent arterioles.
Hypertension Oct, 2011 | Pubmed ID: 21859962
Impact of fibroblast growth factor-binding protein-1 expression on angiogenesis and wound healing.
The American journal of pathology Nov, 2011 | Pubmed ID: 21945411
p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.
Hypertension Feb, 2012 | Pubmed ID: 22184329
Role of the nuclear receptor coactivator AIB1/SRC-3 in angiogenesis and wound healing.
The American journal of pathology Apr, 2012 | Pubmed ID: 22342158
Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass.
American journal of physiology. Renal physiology Jul, 2012 | Pubmed ID: 22492941
Pleiotrophin (PTN) expression and function and in the mouse mammary gland and mammary epithelial cells.
PloS one , 2012 | Pubmed ID: 23077670
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.
Oncotarget Oct, 2012 | Pubmed ID: 23100451
Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy.
Cell cycle (Georgetown, Tex.) Dec, 2012 | Pubmed ID: 23151455
ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers.
Frontiers in oncology , 2012 | Pubmed ID: 23267434
Transcriptional repression of AIB1 by FoxG1 leads to apoptosis in breast cancer cells.
Molecular endocrinology (Baltimore, Md.) Jul, 2013 | Pubmed ID: 23660594
Late failure of a split-thickness skin graft in the setting of homozygous factor V Leiden mutation: a case report and correlative animal model from the Wound Etiology and Healing (WE-HEAL) study.
International wound journal Sep, 2013 | Pubmed ID: 24028566
Utility of a human-mouse xenograft model and in vivo near-infrared fluorescent imaging for studying wound healing.
International wound journal Dec, 2015 | Pubmed ID: 24373153
Recurrence of early stage colon cancer predicted by expression pattern of circulating microRNAs.
PloS one , 2014 | Pubmed ID: 24400111
Regulation of HER2 oncogene transcription by a multifunctional coactivator/corepressor complex.
Molecular endocrinology (Baltimore, Md.) Jun, 2014 | Pubmed ID: 24678732
SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker.
Oncotarget Mar, 2014 | Pubmed ID: 24681808
Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma.
Science signaling May, 2014 | Pubmed ID: 24803537
Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype.
PloS one , 2014 | Pubmed ID: 24831228
Expression of a Secreted Fibroblast Growth Factor Binding Protein-1 (FGFBP1) in Angioproliferative Kaposi Sarcoma.
Journal of AIDS & clinical research Jun, 2014 | Pubmed ID: 25429350
Thromboxane prostanoid receptors enhance contractions, endothelin-1, and oxidative stress in microvessels from mice with chronic kidney disease.
Hypertension May, 2015 | Pubmed ID: 25733239
Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling.
Oncogene Nov, 2015 | Pubmed ID: 25772246
Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic ductal adenocarcinoma.
BMC genomics , 2015 | Pubmed ID: 25923219
Circulating DNA and Micro-RNA in Patients with Pancreatic Cancer.
Pancreatic disorders & therapy Jun, 2015 | Pubmed ID: 26161297
Cell density regulates cancer metastasis via the Hippo pathway.
Future oncology (London, England) Nov, 2015 | Pubmed ID: 26561730
Increased Pleiotrophin Concentrations in Papillary Thyroid Cancer.
PloS one , 2016 | Pubmed ID: 26914549
Circulating microRNA profile predicts disease progression in patients receiving second-line treatment of lapatinib and capecitabine for metastatic pancreatic cancer.
Oncology letters Mar, 2016 | Pubmed ID: 26998056
Differential effects of superoxide and hydrogen peroxide on myogenic signaling, membrane potential, and contractions of mouse renal afferent arterioles.
American journal of physiology. Renal physiology Jun, 2016 | Pubmed ID: 27053691
Midkine and Pleiotrophin Concentrations in Amniotic Fluid in Healthy and Complicated Pregnancies.
PloS one , 2016 | Pubmed ID: 27089523
Circulating biomarkers to monitor cancer progression and treatment.
Computational and structural biotechnology journal , 2016 | Pubmed ID: 27358717
Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion.
Oncogene 02, 2017 | Pubmed ID: 27375028
Superoxide and hydrogen peroxide counterregulate myogenic contractions in renal afferent arterioles from a mouse model of chronic kidney disease.
Kidney international 09, 2017 | Pubmed ID: 28396118
Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt.
PloS one , 2017 | Pubmed ID: 28700668
The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation.
The Journal of investigative dermatology 01, 2018 | Pubmed ID: 28864076
Midkine and pleiotrophin concentrations in needle biopsies of breast and lung masses.
Cancer biomarkers : section A of Disease markers Sep, 2017 | Pubmed ID: 28946562
Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib.
Clinical and translational medicine Oct, 2017 | Pubmed ID: 28980224
Circulating cell-free DNA mutation patterns in early and late stage colon and pancreatic cancer.
Cancer genetics Dec, 2017 | Pubmed ID: 29153095
Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein).
Hypertension (Dallas, Tex. : 1979) 01, 2018 | Pubmed ID: 29158353
NRF2 prevents hypertension, increased ADMA, microvascular oxidative stress, and dysfunction in mice with two weeks of ANG II infusion.
American journal of physiology. Regulatory, integrative and comparative physiology 03, 2018 | Pubmed ID: 29167164
The PPARγ agonist efatutazone delays invasive progression and induces differentiation of ductal carcinoma in situ.
Breast cancer research and treatment May, 2018 | Pubmed ID: 29350308
Left Ventricular Dysfunction in Cancer Treatment: Is it Relevant?
JACC. Heart failure 02, 2018 | Pubmed ID: 29413379
Fenofibrate improves vascular endothelial function and contractility in diabetic mice.
Redox biology 01, 2019 | Pubmed ID: 30296701
High Salt Enhances Reactive Oxygen Species and Angiotensin II Contractions of Glomerular Afferent Arterioles From Mice With Reduced Renal Mass.
Hypertension (Dallas, Tex. : 1979) 11, 2018 | Pubmed ID: 30354808
Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism.
Scientific reports 10, 2018 | Pubmed ID: 30374109
Reprint of: Circulating cell-free DNA mutation patterns in early and late stage colon and pancreatic cancer.
Cancer genetics 12, 2018 | Pubmed ID: 30447903
Single-Molecule Real-Time (SMRT) Full-Length RNA-Sequencing Reveals Novel and Distinct mRNA Isoforms in Human Bone Marrow Cell Subpopulations.
Genes 03, 2019 | Pubmed ID: 30934798
Short- and Long-Term Effects of CDK4/6 Inhibition on Early-Stage Breast Cancer.
Molecular cancer therapeutics 12, 2019 | Pubmed ID: 31451564
Loss of ANCO1 repression at AIB1/YAP targets drives breast cancer progression.
EMBO reports Jan, 2020 | Pubmed ID: 31788936
Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice.
Gastroenterology 03, 2021 | Pubmed ID: 33307028
An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer.
Cancer research 08, 2021 | Pubmed ID: 34135000
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