Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

This work describes a nanoimprinting lithography method to fabricate high-quality sensing arrays that work on the principle of extraordinary optical transmission. The biosensor is low-cost, robust, easy to use, and can detect cardiac troponin I in serum at clinically relevant concentrations (99^th percentile cutoff ∼10-400 pg/mL, depending on the assay).