Performing the Game Set Enrichment Analysis (GSEA)
5:46
Comparing the GSEA Results and Identifying the Optimal Animal Model
7:55
Results: Overlap of Pathway Regulation Identifies Suitable and Unsuitable Animal Models
8:49
Conclusion
Transcrição
The overall goal of this procedure is to identify the appropriate animal model for translational research questions. This method can help answer one key question in translational research and that is, how can I select an appropriate animal model f
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We provide a standardized protocol for the use of gene set enrichment analysis of transcriptomic data to identify an ideal mouse model for translational research.
This protocol can be used with DNA microarray and RNA sequencing data and can further be extended to other omics data if data are available.