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JoVE Journal

Immunology and Infection

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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

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10:26 min

January 20th, 2019

January 20th, 2019

11,817 Views

0:04

Title

0:52

B Cell Amplification and Differentiation

3:44

Plasmablastic Cell Generation

4:36

Early Plasma Cell Generation

5:21

Long-lived Plasma Cell Generation

6:29

Molecular Atlas of B to PC Differentiation

7:33

Results: Epigenetic Factor Expression in Normal Plasma Cell Differentiation

9:01

Conclusion

Transcrição

Plasma cells are rare cells with 30 differentiation stages taking place in anatomic locations that impair full biological characterization, particularly in human. Our in vitro B2 plasma cell differentiation model reproduces the sequential cell dif

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Using multi-step culture systems, we report an in vitro B cell to plasma cell differentiation model.

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