Establishment of Zebrafish‐Based Patient‐Derived Xenografts (zPDX)
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Treatment and Imaging
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Results: Establishment of Zebrafish‐Based Patient‐Derived Xenografts (zPDXs) from Primary Human Pancreatic Adenocarcinoma
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Conclusion
Transcrição
Zebrafish patient-derived xenograft is a powerful preclinical model to predict cancer patient chemosensitivity profile in vivo. The protocol describe the generation of the model starting from a patient surgical specimen. By xenografting a small ti
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Preclinical models aim to advance the knowledge of cancer biology and predict treatment efficacy. This paper describes the generation of zebrafish-based patient-derived xenografts (zPDXs) with tumor tissue fragments. The zPDXs were treated with chemotherapy, the therapeutic effect of which was assessed in terms of cell apoptosis of the transplanted tissue.