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Abstract

Medicine

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published: February 17th, 2023

DOI:

10.3791/64660

1School of Intelligent Medicine, Chengdu University of Traditional Chinese Medicine, 2School of Chinese Medicine, Hong Kong Baptist University

* These authors contributed equally

Abstract

A systematic review and meta-analysis were conducted to evaluate the clinical effectiveness and safety of Shugan Jieyu capsules for treating insomnia by searching seven databases up to February 21, 2022. The study was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of the studies was assessed using the risk of bias assessment tool. This article describes in detail how to retrieve and screen the literature. The detailed steps for conducting the meta-analysis are also included in the protocol. Fourteen studies were found to be eligible, including 1,283 insomnia patients (644 with and 639 without Shugan Jieyu capsules at baseline). The meta-analysis showed a better total clinical effectiveness (odds ratio [OR]: 5.71, 95% confidence interval [CI]: 3.56 to 9.15) and a lower Pittsburgh Sleep Quality Index (PSQI) score (mean difference [MD]: −2.95, 95% CI: −4.97 to −0.93) with combined Shugan Jieyu capsules and Western medicine compared to Western medicine alone. The secondary outcomes showed that the Shugan Jieyu capsule group had significantly reduced adverse reactions and improvements in sleep duration, night awakening, nightmares with excessive dreaming, daytime sleepiness, and low energy. Further multicenter randomized trials must be encouraged to provide more concrete evidence on whether Shugan Jieyu capsules are beneficial in routine clinical practice.

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Here Is A Summary Of The Key Keywords From The Provided Text Meta analysis Insomnia Shugan Jieyu Capsules Effectiveness And Safety Literature Search And Screening Data Extraction Risk Of Bias Assessment Quality Of Evidence PubMed PRISMA Flow Chart RevMan Software Risk Of Bias Assessment Forest Plot Systematic Review The Text Describes The Process Of Conducting A Meta analysis On The Effectiveness And Safety Of Shugan Jieyu Capsules For The Treatment Of Insomnia

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