Sven G. Meuth

Contribution of TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 channels to the control of activity modes in thalamocortical neurons.

Modulation of neuronal activity by the endogenous pentapeptide QYNAD.

Influence of Ca2+-binding proteins and the cytoskeleton on Ca2+-dependent inactivation of high-voltage activated Ca2+ currents in thalamocortical relay neurons.

The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons.

Effects of divalent cations and spermine on the K+ channel TASK-3 and on the outward current in thalamic neurons.

T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression.

Membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels.

T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy.

Specific expression of low-voltage-activated calcium channel isoforms and splice variants in thalamic local circuit interneurons.

Multiple sclerosis therapy: an update on recently finished trials.

CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing.

The two-pore domain potassium channel TASK3 functionally impacts glioma cell death.

Muscarinic ACh receptor-mediated control of thalamic activity via G(q)/G (11)-family G-proteins.

TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 critically influence T lymphocyte effector functions.

Reciprocal modulation of I (h) and I (TASK) in thalamocortical relay neurons by halothane.

Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis.

A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis.

The trials and errors in MS therapy.

Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation.

Mismatch and conflict: neurophysiological and behavioral evidence for conflict priming.

The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice.

Transient widespread blood-brain barrier alterations after cerebral photothrombosis as revealed by gadofluorine M-enhanced magnetic resonance imaging.

Intercellular exchanges of membrane fragments (trogocytosis) between human muscle cells and immune cells: a potential mechanism for the modulation of muscular immune responses.

Recent clinical trials and future therapies.

Platelet derived bFGF mediates vascular integrative mechanisms of mesenchymal stem cells in vitro.

Antigen-specific blockade of lethal CD8 T-cell mediated autoimmunity in a mouse model of multiple sclerosis.

CD8+ T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability.

TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system.

Comment on "Functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse".

Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte-directed CD8(+) T cell attack.

STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death.

Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death.

Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation.

Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve.

Multifocal motor neuropathy: update on clinical characteristics, pathophysiological concepts and therapeutic options.

Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.

A pure cerebellar syndrome with corresponding ponto-cerebellar atrophy in acquired hepatocerebral degeneration.

Report on the 1st scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Mittenwalde/Motzen, Germany, Oct. 30th - Nov. 1st, 2009.

From the background to the spotlight: TASK channels in pathological conditions.

Upregulation of K2P5.1 potassium channels in multiple sclerosis.

Therapeutic approaches to multiple sclerosis: an update on failed, interrupted, or inconclusive trials of immunomodulatory treatment strategies.

Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9).

Therapeutic approaches to multiple sclerosis: an update on failed, interrupted, or inconclusive trials of neuroprotective and alternative treatment strategies.

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.

Glatiramer acetate attenuates pro-inflammatory T cell responses but does not directly protect neurons from inflammatory cell death.

Temporal pattern of ICAM-I mediated regulatory T cell recruitment to sites of inflammation in adoptive transfer model of multiple sclerosis.

Natalizumab restores evoked potential abnormalities in patients with relapsing-remitting multiple sclerosis.

Active immunization with proteolipid protein (190-209) induces ascending paralysing experimental autoimmune encephalomyelitis in C3H/HeJ mice.

Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking.

Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling.

Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients.

No association between genetic polymorphism at codon 129 of the prion protein gene and primary progressive multiple sclerosis.

Glucocorticoid insensitivity at the hypoxic blood-brain barrier can be reversed by inhibition of the proteasome.

A-type K+ currents in intralaminar thalamocortical relay neurons.

Report on the 2nd scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Oct. 29'th - Oct. 31'st, 2010.

Ion channels in autoimmune neurodegeneration.

Immune mechanisms of new therapeutic strategies in multiple sclerosis-A focus on alemtuzumab.

Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels.

Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex.

Immunological and clinical consequences of treating a patient with natalizumab.

Identification of the muscarinic pathway underlying cessation of sleep-related burst activity in rat thalamocortical relay neurons.

Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 Integrin Mediates Interaction of Melanoma Cells with Platelets: A CONNECTION TO HEMATOGENOUS METASTASIS.

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.

Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.

CD4(+) T cells predominate in cerebrospinal fluid and leptomeningeal and parenchymal infiltrates in cerebral amyloid β-related angiitis.

Report on the 3'rd scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Nov. 4'th - Nov. 6'th, 2011.

CD4(+) CD25(+) FoxP3(+) regulatory T cells suppress cytotoxicity of CD8(+) effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level.

Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis.

Neuron-directed autoimmunity in the central nervous system: entities, mechanisms, diagnostic clues, and therapeutic options.

Adenylyl cyclases: expression in the developing rat thalamus and their role in absence epilepsy.

Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation.

Immune therapy of multiple sclerosis--future strategies.

C1-inhibitor protects from brain ischemia-reperfusion injury by combined antiinflammatory and antithrombotic mechanisms.

Cytotoxic CD8+ T cells and CD138+ plasma cells prevail in cerebrospinal fluid in non-paraneoplastic cerebellar ataxia with contactin-associated protein-2 antibodies.

Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.

The TASK1 channel inhibitor A293 shows efficacy in a mouse model of multiple sclerosis.

Paraneoplastic and non-paraneoplastic autoimmunity to neurons in the central nervous system.

Identification of two-pore domain potassium channels as potent modulators of osmotic volume regulation in human T lymphocytes.

Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.

Report on the 4'th scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Nov. 2'nd - Nov. 4'th, 2012.

Ca(2+)-dependent large conductance K(+) currents in thalamocortical relay neurons of different rat strains.

Correction: Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9).

Thalamic involvement in patients with neurologic impairment due to Shiga toxin 2.

Get the rhythm: modeling neuronal activity.

The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood-brain-barrier damage, inflammation and thrombosis.

4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis.

Rasmussen encephalitis treated with natalizumab.

L-Selectin is a possible biomarker for individual PML risk in natalizumab-treated MS patients.

Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS.

Protein kinase Cβ as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis.

Targeting ion channels for the treatment of autoimmune neuroinflammation.

FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection.

Excitotoxic neuronal cell death during an oligodendrocyte-directed CD8+ T cell attack in the CNS gray matter.

DTI detects water diffusion abnormalities in the thalamus that correlate with an extremity pain episode in a patient with multiple sclerosis.

A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels.

CD4+NKG2D+ T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation.

Evans syndrome associated with sterile inflammation of the central nervous system: a case report.

Report on the 5'th scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Oct. 25th - Oct. 27th, 2013.

Ischemia-induced cell depolarization: does the hyperpolarization-activated cation channel HCN2 affect the outcome after stroke in mice?

TREK-King the Blood-Brain-Barrier.

Glatiramer acetate does not protect from acute ischemic stroke in mice.

Early Detection of Widespread Progressive Brain Injury after Cardiac Arrest: A Single Case DTI and Post-Mortem Histology Study.

Blocking of α4 integrin does not protect from acute ischemic stroke in mice.

Human CD4+ HLA-G+ regulatory T cells are potent suppressors of graft-versus-host disease in vivo.

Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity.

Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis.

Effects of glatiramer acetate in a spontaneous model of autoimmune neuroinflammation.

Regionally specific expression of high-voltage-activated calcium channels in thalamic nuclei of epileptic and non-epileptic rats.

Transient receptor potential melastatin subfamily member 2 cation channel regulates detrimental immune cell invasion in ischemic stroke.

C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation.

Clinical relevance of specific T-cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease.

Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons.

CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke.

The two-pore domain potassium channel KCNK5 deteriorates outcome in ischemic neurodegeneration.

The role of two-pore-domain background K⁺ (K₂p) channels in the thalamus.

Immunotherapy of multiple sclerosis.

The CNS under pathophysiologic attack-examining the role of K2P channels.

Effects of blood transportation on human peripheral mononuclear cell yield, phenotype and function: implications for immune cell biobanking.

Long-term efficacy of alemtuzumab in polymyositis.

Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons.

A human post-mortem brain model for the standardization of multi-centre MRI studies.

Increased cortical curvature reflects white matter atrophy in individual patients with early multiple sclerosis.

Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation.

Thalamic Kv 7 channels: pharmacological properties and activity control during noxious signal processing.

Report on the 6th scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Oct. 31th - Nov. 2nd, 2014.

Evidence for early, non-lesional cerebellar damage in patients with multiple sclerosis: DTI measures correlate with disability, atrophy, and disease duration.

Pharmacological Approaches to Delaying Disability Progression in Patients with Multiple Sclerosis.

A Case Report on Juvenile Neuromyelitis Optica: Early Onset, Long Remission Period, and Atypical Treatment Response.

Assessment of immune functions and MRI disease activity in relapsing-remitting multiple sclerosis patients switching from natalizumab to fingolimod (ToFingo-Successor).

The two-pore domain K2 P channel TASK2 drives human NK-cell proliferation and cytolytic function.

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein.

Effect of Sativex on spasticity-associated symptoms in patients with multiple sclerosis.

Recovery of thalamic microstructural damage after Shiga toxin 2-associated hemolytic-uremic syndrome.

Blood-brain barrier modeling: challenges and perspectives.

Alemtuzumab in Multiple Sclerosis: Mechanism of Action and Beyond.

Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms.

Platelets induce apoptosis via membrane-bound FasL.

CD8(+) T Cell-Mediated Neuronal Dysfunction and Degeneration in Limbic Encephalitis.

Limbic Encephalitis: Potential Impact of Adaptive Autoimmune Inflammation on Neuronal Circuits of the Amygdala.

The role of ion channels in malignant brain tumors.

Physiological Dynamics in Demyelinating Diseases: Unraveling Complex Relationships through Computer Modeling.

Neurocognitive decline in HIV patients is associated with ongoing T-cell activation in the cerebrospinal fluid.

Early and Degressive Putamen Atrophy in Multiple Sclerosis.

Effects of diazoxide in multiple sclerosis: A randomized, double-blind phase 2 clinical trial.

PML risk stratification using anti-JCV antibody index and L-selectin.

Changes in different parameters, lymphocyte proliferation and hematopoietic progenitor colony formation in EAE mice treated with myelin oligodendrocyte glycoprotein.

Successful Replication of GWAS Hits for Multiple Sclerosis in 10,000 Germans Using the Exome Array.

Case report of bilateral relapsing-remitting sciatic nerve palsy during two pregnancies.

An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.

Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity.

The NKG2D-IL-15 signaling pathway contributes to T-cell mediated pathology in inflammatory myopathies.

Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model.

CD4(+)HLA-G(+) regulatory T cells: Molecular signature and pathophysiological relevance.

Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society.

Early silent microstructural degeneration and atrophy of the thalamocortical network in multiple sclerosis.

ALAIN01--Alemtuzumab in autoimmune inflammatory neurodegeneration: mechanisms of action and neuroprotective potential.

Simultaneous early-onset immune thrombocytopenia and autoimmune thyroid disease following alemtuzumab treatment in relapsing-remitting multiple sclerosis.

Editorial: Limbic Encephalitis: Autoimmune Impact on Inhibitory GABAergic Neuronal Pathways in Temporal Lobe Epilepsy.

Failed, interrupted and inconclusive trials on relapsing multiple sclerosis treatment: update 2010-2015.

Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Evidence of a pathogenic role for CD8(+) T cells in anti-GABAB receptor limbic encephalitis.

Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis.

Human T cells in silico: Modelling their electrophysiological behaviour in health and disease.

Thalamocortical-auditory network alterations following cuprizone-induced demyelination.

The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion.

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.

General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation.

Variations in multiple sclerosis practice within Europe - Is it time for a new treatment guideline?

Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets.

The potassium channels TASK2 and TREK1 regulate functional differentiation of murine skeletal muscle cells.

The quality of cortical network function recovery depends on localization and degree of axonal demyelination.

Tau Tubulin Kinase TTBK2 Sensitivity of Glutamate Receptor GluK2.

Platelet derived FasL contributes to apoptosis in stroke.

B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity.

Dichoptic Metacontrast Masking Functions to Infer Transmission Delay in Optic Neuritis.

14-3-3 Proteins regulate K2P 5.1 surface expression on T lymphocytes.

The Inflammatory Role of Platelets: Translational Insights from Experimental Studies of Autoimmune Disorders.

Alemtuzumab treatment alters circulating innate immune cells in multiple sclerosis.

Prothrombin and factor X are elevated in multiple sclerosis patients.

Acute cholecystitis during treatment with alemtuzumab in 3 patients with RRMS.

Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease.

Resistance to renal denervation therapy - Identification of underlying mechanisms by analysis of differential DNA methylation.

An Enigmatic Case of Acute Mercury Poisoning: Clinical, Immunological Findings and Platelet Function.

Amygdala enlargement and emotional responses in (autoimmune) temporal lobe epilepsy.

In Vitro Analyses of Novel HCN4 Gene Mutations.

Specific T-cell activation in peripheral blood and cerebrospinal fluid in central disorders of hypersomnolence.

TPP2 mutation associated with sterile brain inflammation mimicking MS.

An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis.

Neutrophil granulocytes promote flow stagnation due to dynamic capillary stalls following experimental stroke.

Teriflunomide treatment is associated with optic nerve recovery in early multiple sclerosis.

Impact of Diverse Ion Channels on Regulatory T Cell Functions.

Ocrelizumab Extended Interval Dosing in Multiple Sclerosis in Times of COVID-19.

Mini-Review: Two Brothers in Crime - The Interplay of TRESK and TREK in Human Diseases.

An optimized and validated protocol for inducing chronic experimental autoimmune encephalomyelitis in C57BL/6J mice.

Thinking outside the box: non-canonical targets in multiple sclerosis.

[Multiple sclerosis: interventions to halt disease : Which patients can be considered for autologous stem cell transplantation].

Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells.

Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis.

Immunoadsorption versus double-dose methylprednisolone in refractory multiple sclerosis relapses.

Real-world evidence on siponimod treatment in patients with secondary progressive multiple sclerosis.

Myositis in Germany: epidemiological insights over 15 years from 2005 to 2019.

Driving time-based identification of gaps in specialised care coverage: An example of neuroinflammatory diseases in Germany.

Treatment of autoimmunity: The impact of disease-modifying therapies in multiple sclerosis and comorbid autoimmune disorders.

Introducing electronic monitoring of disease activity in patients with chronic inflammatory demyelinating polyneuropathy (EMDA CIDP): trial protocol of a proof of concept study.

Senescent fibro-adipogenic progenitors are potential drivers of pathology in inclusion body myositis.