Chapter 4
Pharmacokinetics: Drug Distribution and Protein Binding
İlaç Dağıtımı: Genel Bakış
Distribution refers to the two-way movement of a drug between different compartments within the body.
It is a passive process driven by the concentration ...
İlaç Dağılımını Etkileyen Faktörler: Doku Geçirgenliği
Drug distribution across biological membranes to target tissues relies on the drug's physicochemical properties, such as molecular size, ionization ...
İlaç Dağılımını Etkileyen Faktörler: Fizyolojik Engeller
Drug distribution is governed by several physiological barriers.
The simple capillary endothelial barrier limits the passage of drugs larger than 600 ...
İlaç Dağılımını Etkileyen Faktörler: Organ Perfüzyon Hızı
Drug distribution can be perfusion rate-limited, particularly when the drug is highly lipophilic, and the membrane to cross is highly permeable.
The ...
İlaç Dağılımını Etkileyen Faktörler: Çeşitli Faktörler
Drug distribution can be affected by various factors.
It can vary with age due to differences in body composition. For instance, older adults have less ...
Dağıtım Hacmi
The apparent volume of distribution or Vd is a key pharmacokinetic parameter signifying the hypothetical body fluid volume into which a drug disperses.
It ...
Protein-İlaç Bağlanması: Mekanizma ve Kinetik
Protein-drug binding is the interaction between drugs and proteins in the body.
It can be either intracellular binding, which involves drug interactions ...
Kan bileşenlerine ilaç bağlanması
When drugs enter the systemic circulation, they interact with blood components like human serum albumin or HSA, α1-acid glycoprotein or AAG, ...
Doku-İlaç Bağlanması: İlaçların Lokalizasyonu ve Önemi
Body tissues comprise 40-90% of body weight depending on body composition. They can serve as drug storage sites, competing with plasma binding sites.
...
Protein-İlaç Bağlanması: Tayin Yöntemleri
Protein-drug binding is determined through indirect and direct methods.
Indirect methods involve isolating the bound drug from its free form in biological ...
Protein-İlaç Bağlanmasını Etkileyen Faktörler: İlaca İlişkili Faktörler
Protein-drug binding can be affected by various drug-related factors.
The degree of protein binding is closely related to a drug's lipophilicity, with ...
Protein-İlaç Bağlanmasını Etkileyen Faktörler: Proteinle İlgili Faktörler
Drug binding to proteins depends on various factors, including physicochemical properties, protein concentration, disease states, and the number of ...
Protein-İlaç Bağlanmasını Etkileyen Faktörler: İlaç Etkileşimleri
Drug displacement interactions arise when drugs compete for the same binding site, leading to displacement.
The extent of displacement depends on the ...
Protein-İlaç Bağlanmasını Etkileyen Faktörler: Hastaya Bağlı Faktörler
Protein-drug binding varies with many patient-related factors.
Age impacts binding due to varying protein content in different age groups. Neonates ...
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