Chapter 4
Pharmacokinetics: Drug Distribution and Protein Binding
Distribution des médicaments : aperçu
Distribution refers to the two-way movement of a drug between different compartments within the body.
It is a passive process driven by the concentration ...
Facteurs affectant la distribution des médicaments : Perméabilité tissulaire
Drug distribution across biological membranes to target tissues relies on the drug's physicochemical properties, such as molecular size, ionization ...
Facteurs affectant la distribution des médicaments : barrières physiologiques
Drug distribution is governed by several physiological barriers.
The simple capillary endothelial barrier limits the passage of drugs larger than 600 ...
Facteurs affectant la distribution des médicaments : taux de perfusion d’organes
Drug distribution can be perfusion rate-limited, particularly when the drug is highly lipophilic, and the membrane to cross is highly permeable.
The ...
Facteurs influant sur la distribution des drogues : facteurs divers
Drug distribution can be affected by various factors.
It can vary with age due to differences in body composition. For instance, older adults have less ...
Volume de distribution
The apparent volume of distribution or Vd is a key pharmacokinetic parameter signifying the hypothetical body fluid volume into which a drug disperses.
It ...
Liaison protéine-médicament : mécanisme et cinétique
Protein-drug binding is the interaction between drugs and proteins in the body.
It can be either intracellular binding, which involves drug interactions ...
Liaison du médicament aux composants sanguins
When drugs enter the systemic circulation, they interact with blood components like human serum albumin or HSA, α1-acid glycoprotein or AAG, ...
Liaison tissulaire-médicament : localisation des médicaments et sa signification
Body tissues comprise 40-90% of body weight depending on body composition. They can serve as drug storage sites, competing with plasma binding sites.
...
Liaison protéine-médicament : méthodes de détermination
Protein-drug binding is determined through indirect and direct methods.
Indirect methods involve isolating the bound drug from its free form in biological ...
Facteurs affectant la liaison protéine-médicament : facteurs liés au médicament
Protein-drug binding can be affected by various drug-related factors.
The degree of protein binding is closely related to a drug's lipophilicity, with ...
Facteurs affectant la liaison protéine-médicament : facteurs liés aux protéines
Drug binding to proteins depends on various factors, including physicochemical properties, protein concentration, disease states, and the number of ...
Facteurs affectant la liaison protéine-médicament : interactions médicamenteuses
Drug displacement interactions arise when drugs compete for the same binding site, leading to displacement.
The extent of displacement depends on the ...
Facteurs affectant la liaison protéine-médicament : facteurs liés au patient
Protein-drug binding varies with many patient-related factors.
Age impacts binding due to varying protein content in different age groups. Neonates ...
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