Chapter 4
Pharmacokinetics: Drug Distribution and Protein Binding
Распространение лекарственных средств: обзор
Distribution refers to the two-way movement of a drug between different compartments within the body.
It is a passive process driven by the concentration ...
Факторы, влияющие на распределение лекарств: проницаемость тканей
Drug distribution across biological membranes to target tissues relies on the drug's physicochemical properties, such as molecular size, ionization ...
Факторы, влияющие на распределение лекарств: физиологические барьеры
Drug distribution is governed by several physiological barriers.
The simple capillary endothelial barrier limits the passage of drugs larger than 600 ...
Факторы, влияющие на распределение лекарств: скорость перфузии органов
Drug distribution can be perfusion rate-limited, particularly when the drug is highly lipophilic, and the membrane to cross is highly permeable.
The ...
Факторы, влияющие на распределение лекарственных средств: разные факторы
Drug distribution can be affected by various factors.
It can vary with age due to differences in body composition. For instance, older adults have less ...
Объем распространения
The apparent volume of distribution or Vd is a key pharmacokinetic parameter signifying the hypothetical body fluid volume into which a drug disperses.
It ...
Связывание белка с лекарством: механизм и кинетика
Protein-drug binding is the interaction between drugs and proteins in the body.
It can be either intracellular binding, which involves drug interactions ...
Связывание препарата с компонентами крови
When drugs enter the systemic circulation, they interact with blood components like human serum albumin or HSA, α1-acid glycoprotein or AAG, ...
Тканево-лекарственное связывание: локализация лекарств и ее значение
Body tissues comprise 40-90% of body weight depending on body composition. They can serve as drug storage sites, competing with plasma binding sites.
...
Связывание белка с лекарственным средством: методы определения
Protein-drug binding is determined through indirect and direct methods.
Indirect methods involve isolating the bound drug from its free form in biological ...
Факторы, влияющие на связывание белка с лекарственным средством: факторы, связанные с лекарственными препаратами
Protein-drug binding can be affected by various drug-related factors.
The degree of protein binding is closely related to a drug's lipophilicity, with ...
Факторы, влияющие на связывание белка с лекарством: факторы, связанные с белком
Drug binding to proteins depends on various factors, including physicochemical properties, protein concentration, disease states, and the number of ...
Факторы, влияющие на связывание белка с лекарственным средством: лекарственное взаимодействие
Drug displacement interactions arise when drugs compete for the same binding site, leading to displacement.
The extent of displacement depends on the ...
Факторы, влияющие на связывание белка с лекарственным средством: факторы, связанные с пациентом
Protein-drug binding varies with many patient-related factors.
Age impacts binding due to varying protein content in different age groups. Neonates ...
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