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Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices

DOI :

10.3791/1884-v

July 14th, 2010

July 14th, 2010

22,751 Views

1Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University

One feature of Alzheimer's Disease is the elevation of Aβ1-42 peptide. Here we provide a protocol for preparing synthetic Aβ1-42 oligomers, which impairs hippocampal Long-Term Potentiation, a cellular correlate of memory. This procedure is useful for investigating mechanisms of Aβ-induced pathology and drug screening.

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Oligomeric amyloid1 42

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