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Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

DOI :

10.3791/2252-v

13:59 min

October 9th, 2010

October 9th, 2010

24,710 Views

1Institute for Behavioral Genetics, University of Colorado, 2Integrative Physiology, University of Colorado

The intensely studied nematode worm Caenorhabditis elegans can be transgenically engineered to express the human β-amyloid peptide (Aβ). Induced expression of Aβ in C. elegans muscle leads to a rapid, reproducible paralysis phenotype that can be used to monitor treatments that modulate Aβ toxicity.

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