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A Caenorhabditis elegans Model System for Amylopathy Study

DOI :

10.3791/50435-v

May 17th, 2013

May 17th, 2013

10,343 Views

1Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey

We describe methods to study aspects of amylopathies in the worm C. elegans. We show how to construct worms expressing human Aβ42 in neurons and how to test their function in behavioral assays. We further show how to obtain primary neuronal cultures that can be used for pharmacological testing.

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