July 29th, 2011
•Here, we established a method for drug efficacy testing with surgical specimens of brain tumors, termed “tumor explant method”. With this method, we can evaluate drug efficacy without breaking the microenvironment of solid tumors. To validate reliability of this method, we describe representative data with our glioma specimen treated with the current first-line chemotherapeutic agent, temozolomide.
Tags
Related Videos
A Novel Surgical Approach for Intratracheal Administration of Bioactive Agents in a Fetal Mouse Model
Improved Protocol For Laser Microdissection Of Human Pancreatic Islets From Surgical Specimens
A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl
An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
Method for Obtaining Primary Ovarian Cancer Cells From Solid Specimens
Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
A Novel Murine Model of Arteriovenous Fistula Failure: The Surgical Procedure in Detail
A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved