JoVE Logo
Faculty Resource Center

Sign In

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

DOI :

10.3791/52200-v

10:08 min

December 2nd, 2014

December 2nd, 2014

15,588 Views

1Department of Biomedical Engineering, Johns Hopkins University, 2Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 3Department of Medicine (Cardiology), Johns Hopkins University, 4The Australian School of Advanced Medicine, Macquarie University

We describe a technique for measuring aortic stiffness from its pressure-diameter relationship in vivo in mice. Aortic diameter is recorded by ultrasound and aortic pressure is measured invasively with a solid-state pressure catheter. Blood pressure is changed incrementally and the resulting diameter is measured.

Tags

Ascending Aortic Stiffness

-- Views

Related Videos

article

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

article

Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease

article

In vivo 19F MRI for Cell Tracking

article

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

article

Ultrasound-guided Transthoracic Intramyocardial Injection in Mice

article

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

article

Depletion of Mouse Cells from Human Tumor Xenografts Significantly Improves Downstream Analysis of Target Cells

article

Ultrasound-based Pulse Wave Velocity Evaluation in Mice

article

Minimally Invasive Transverse Aortic Constriction in Mice

article

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved