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A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

DOI :

10.3791/52859-v

June 22nd, 2015

June 22nd, 2015

14,451 Views

1Department of Neuroscience, Oberlin College

This protocol describes how to temporarily and remotely silence neuronal activity in discrete brain regions while rats are engaged in learning and memory tasks. The approach combines pharmacogenetics (Designer-Receptors-Exclusively-Activated-by-Designer-Drugs) with a behavioral paradigm (sensory preconditioning) that is designed to distinguish between different components of learning.

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Keywords Pharmacogenetics

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