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Bioluminescence Imaging of an Immunocompetent Animal Model for Glioblastoma

DOI :

10.3791/53287-v

9:17 min

January 15th, 2016

January 15th, 2016

14,284 Views

1Department of Neurological Surgery, University of California San Francisco, 2Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, 3Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine

GL261 glioma cells provide a useful immunocompetent animal model of glioblastoma. The goals of this protocol are to demonstrate proper techniques for monitoring intracranial tumor growth using in vivo bioluminescence imaging, and to verify the utility of luciferase-modified GL261 cells for studying tumor immunology and immunotherapeutic approaches for treating glioblastoma.

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Keywords Bioluminescence Imaging

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