A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds

10.1K Views

•

13:34 min

•

April 6th, 2016

DOI :

10.3791/53885-v

April 6th, 2016

•

Claudia Göttlich*¹, Lena C. Müller*¹, Meik Kunz*³, Franziska Schmitt¹, Heike Walles¹^,⁴, Thorsten Walles², Thomas Dandekar³, Gudrun Dandekar¹^,⁴, Sarah L. Nietzer¹

¹Department of Tissue Engineering and Regenerative Medicine (TERM), University Hospital Wuerzburg, ²Department of Cardiothoracic Surgery, University Hospital Wuerzburg, ³Department of Bioinformatics, University Wuerzburg, ⁴Translational Center Wuerzburg, Fraunhofer Institute Interfacial Engineering and Biotechnology IGB

Summary

Explore More Videos

Keywords 3D Tissue Engineering

Mutational Backgrounds

Non small Cell Lung Cancer

Targeted Therapies

Cell specific Responses

Pre clinical Drug Testing

Tumor Entities

Drug Response Predictions

Chapters in this video

0:05

Title

1:00

Dynamic Culture Conditions and Static Tumor Model Gefitinib Treatment

2:35

ELISA Samples Collection and Proliferation Index Determination

5:21

In Silico Tumor Model Generation and Anti-EGFR Therapy Simulation in HCC827 Cells

7:13

In Silico Simulation Using SQUAD

10:32

Results: The Effects of Gefitinib Treatment on Cell Growth in Static and Dynamic Tumor Model Systems

12:42

Conclusion

Related Videos

11:12

Tissue Engineering of a Human 3D in vitro Tumor Test System

21.2K Views

13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

11.9K Views

12:16

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

10.4K Views

09:23

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

20.8K Views

06:17

Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue

12.4K Views

10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

6.3K Views

09:57

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

7.2K Views

09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

9.8K Views

08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

7.0K Views

07:55

Pancreatic Tissue-Derived Extracellular Matrix Bioink for Printing 3D Cell-Laden Pancreatic Tissue Constructs

10.8K Views