Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

7.6K Views

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11:58 min

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March 8th, 2018

DOI :

10.3791/55440-v

March 8th, 2018

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Simon Beaudoin¹, Michel Paquette¹, Laurent Fafard-Couture¹, Mylene A. Tremblay¹, Roger Lecomte¹^,²^,³, Brigitte Guérin¹^,²^,³, Jeffrey V. Leyton¹^,²^,³

¹Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, ²Sherbrooke Molecular Imaging Center (CIMS), Université de Sherbrooke, ³Sherbrooke Institute of Pharmacology

Summary

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Keywords Antibody conjugates

Viral derived Peptides

Cellular Accumulation

Monoclonal Antibodies

Chapters in this video

0:05

Title

1:07

Confocal Microscopy for Intracellular Accumulation Evaluation

4:49

Radiolabeled AC Construction and Cellular Fractionation for the Evaluation of ⁶⁴Cu Intracellular Delivery Efficiency

8:23

PET Imaging Evaluation of Tumor Targeting

9:22

Results: Evaluation of Intracellular Accumulation of Antibody Conjugates

11:30

Conclusion

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