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Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening

DOI :

10.3791/55461-v

April 15th, 2017

April 15th, 2017

12,176 Views

1Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf and DZHK (German Center for Cardiovascular Research)

Here, we show the generation of human engineered heart tissue from induced pluripotent stem cells (hiPSC)-derived cardiomyocytes. We present a method to analyze contraction force and exemplary alteration of contraction pattern by the hERG channel inhibitor E-4031. This method shows high level of robustness and suitability for cardiac drug screening.

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Keywords Engineered Heart Tissue

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