The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

11.6K Views

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07:27 min

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October 21st, 2017

DOI :

10.3791/56138-v

October 21st, 2017

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Jully Gogoi-Tiwari¹, Julia Köhn-Gaone¹, Corey Giles², Dirk Schmidt-Arras³, Francis D. Gratte¹^,⁴, Caryn L. Elsegood¹, Geoffrey W. McCaughan⁵^,⁶^,⁷, Grant A. Ramm⁸^,⁹, John K. Olynyk¹⁰^,¹¹, Janina E.E. Tirnitz-Parker¹^,¹²

¹School of Biomedical Sciences & Curtin Health Innovation Research Institute, Curtin University, ²School of Public Health & Curtin Health Innovation Research Institute, Curtin University, ³Institute of Biochemistry, Christian-Albrechts-University, ⁴School of Veterinary and Life Sciences, Murdoch University, ⁵Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, ⁶Royal Prince Alfred Hospital, ⁷A.W. Morrow Gastroenterology and Liver Centre, ⁸QIMR Berghofer Medical Research Institute, ⁹Faculty of Medicine and Biomedical Sciences, The University of Queensland, ¹⁰Fiona Stanley and Fremantle Hospitals, ¹¹School of Medical and Health Sciences, Edith Cowan University, ¹²School of Medicine and Pharmacology, University of Western Australia

Summary

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Keywords Choline deficient Diet

Ethionine supplemented Diet

Liver Progenitor Cell Proliferation

Hepatic Fibrosis

Liver Regeneration

Chronic Liver Disease

Chapters in this video

0:00

Title

1:21

Choline-deficient and ethionine-supplemented diet treatment

2:27

Liver perfusion and isolation

4:53

Results: Representative CDE chronic liver injury model dynamics

6:51

Conclusion

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