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An In Vivo Murine Sciatic Nerve Model of Perineural Invasion

DOI :

10.3791/56857-v

April 23rd, 2018

April 23rd, 2018

11,470 Views

1Department of Surgery, Memorial Sloan Kettering Cancer Center, 2Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, 3Department of Radiation Oncology, Mount Sinai Hospital

We describe an in vivo murine model of perineural invasion by injecting syngeneic pancreatic cancer cells into the sciatic nerve. The model allows for quantification of the extent of nerve invasion, and supports investigation of the cellular and molecular mechanisms of perineural invasion.

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In Vivo Murine Sciatic Nerve Model

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