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Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

DOI :

10.3791/57870-v

September 1st, 2018

September 1st, 2018

7,539 Views

1INSERM, CNRS, Université d'Angers, Université de Nantes, CRCINA, 2Immunotherapy, Graft, Oncology, LabEx IGO, 3Hopital de Nantes, Hotel Dieu

Here, we present a protocol for the preparation and the stereotaxic administration of allogeneic human lymphocytes in immunodeficient mice carrying orthotopic human primary brain tumors. This study provides a proof-of-concept for both the feasibility and the antitumor efficacy of intrabrain-delivered cellular immunotherapies.

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Stereotactic Adoptive Transfer

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