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Translational Orthotopic Models of Glioblastoma Multiforme

DOI :

10.3791/64482-v

February 17th, 2023

February 17th, 2023

1,438 Views

1Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, National Cancer Institute

Here, we describe a preclinical orthotopic mouse model for GBM, established by intracranial injection of cells derived from genetically engineered mouse model tumors. This model displays the disease hallmarks of human GBM. For translational studies, the mouse brain tumor is tracked by in vivo MRI and histopathology.

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