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The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

DOI :

10.3791/58184-v

October 24th, 2018

October 24th, 2018

15,920 Views

1School of Behavioral Science, The Academic College Tel-Aviv-Yaffo, 2Department of Education and Psychology, Open University

Here we present the unpredictable chronic mild stress protocol in mice. This protocol induces a long-term depressive-like phenotype and enables to assess the efficacy of putative antidepressants in reversing the behavioral and neuromolecular depressive-like deficits.

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