The main advantage of this technique is that it adequately translates major neurobiological and behavioral features implicated in the pathogenesis, etiology, and treatment of depression. This method can help answer key questions in understanding t
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Here we present the unpredictable chronic mild stress protocol in mice. This protocol induces a long-term depressive-like phenotype and enables to assess the efficacy of putative antidepressants in reversing the behavioral and neuromolecular depressive-like deficits.