Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

9.5K Views

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07:34 min

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June 2nd, 2019

DOI :

10.3791/58964-v

June 2nd, 2019

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Andrew D. Sligar¹, Gretchen Howe², Julia Goldman³, Patricia Felli², Varsha Karanam¹, Richard W. Smalling²^,⁴, Aaron B. Baker¹^,⁵^,⁶^,⁷

¹Department of Biomedical Engineering, University of Texas at Austin, ²Division of Cardiology, University of Texas McGovern Medical School, ³Center for Laboratory Animal Medicine and Care, UT Health Science Center at Houston, ⁴Memorial Herman Heart and Vascular Center, Texas Medical Center, ⁵Institute for Cellular and Molecular Biology, University of Texas at Austin, ⁶The Institute for Computational Engineering and Sciences, University of Texas at Austin, ⁷Institute for Biomaterials, Drug Delivery and Regenerative Medicine, University of Texas at Austin

Summary

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Preclinical Model

Hind Limb Ischemia

Diabetic Rabbits

Peripheral Arterial Disease

Experimental Treatments

Therapeutic Resistance

Neovascularization

Surgical Procedure

Common Carotid Artery

Vasodilation

Heparin

Guidewire Insertion

Angiographic Catheter

Contrast Agent

Nitroglycerin Injection

Chapters in this video

0:04

Title

0:36

Angiography

3:22

Femoral Artery Isolation

4:57

Repeat Angiography

6:24

Results: Representative Angiographic Analysis of Diabetic and Non-Diabetic Animals

7:04

Conclusion

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