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Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

DOI :

10.3791/59561-v

July 10th, 2019

July 10th, 2019

10,283 Views

1Center for Neuroscience and Regenerative Medicine, Uniformed Services University, 2Department of Anatomy, Physiology, and Genetics, Uniformed Services University, 3Graduate Program in Neuroscience, Uniformed Services University

This protocol demonstrates methodologies for a mouse model of open-skull traumatic brain injury and transplantation of cultured human induced pluripotent stem cell-derived cells into the injury site. Behavioral and histologic tests of outcomes from these procedures are also described in brief.

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Controlled Cortical Impact Model

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