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A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

DOI :

10.3791/60328-v

May 27th, 2021

May 27th, 2021

3,967 Views

1Department of Internal Medicine I - Division of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 2Department of Nephrology, Medical University of Vienna, 3Department of Internal Medicine IV, Medical University Innsbruck

Large genetic screens in model organisms have led to the identification of negative genetic interactions. Here, we describe a data integration workflow using data from genetic screens in model organisms to delineate drug combinations targeting synthetic lethal interactions in cancer.

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Keywords Data Integration

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