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Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

DOI :

10.3791/62311-v

July 24th, 2021

July 24th, 2021

3,932 Views

1Faculty of Medicine and Medical Sciences, University of Balamand, 2Department of Clinical Microbiology, Michigan Health Clinics, 3College of Medicine, Central Michigan University

This protocol describes how to study all possible combinations that can be obtained between four drugs in one single experiment. This method is based on the standard 96-well plate micro dilution assay and the calculation of fractional inhibitory concentrations (FICs) to evaluate the results.

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