JoVE Logo
Faculty Resource Center

Sign In

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

DOI :

10.3791/61313-v

September 9th, 2020

September 9th, 2020

2,397 Views

1Department of Pathology and O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, 2Surgical Discovery Centre, Department of Veterinary Medicine, University of Cambridge

Bone metastasis models do not develop metastasis uniformly or with a 100% incidence. Direct intra-osseous tumor cell injection can result in embolization of the lung. We present our technique modeling primary bone tumors and bone metastasis using solid tumor graft implantation into bone, leading to reproducible engraftment and growth.

Tags

Keywords Primary Bone Tumor

-- Views

Related Videos

article

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

article

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

article

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

article

Acellular and Cellular Lung Model to Study Tumor Metastasis

article

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

article

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

article

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

article

Establishment and Analysis of Three-Dimensional (3D) Organoids Derived from Patient Prostate Cancer Bone Metastasis Specimens and their Xenografts

article

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

article

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved