Comparative Analysis of Experimental Methods to Quantify Animal Activity in Caenorhabditis elegans Models of Mitochondrial Disease

2.6K Views

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05:51 min

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April 4th, 2021

DOI :

10.3791/62244-v

April 4th, 2021

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Manuela Lavorato*¹, Neal D. Mathew*¹, Nina Shah¹, Eiko Nakamaru-Ogiso¹^,², Marni J. Falk¹^,²

¹Mitochondrial Medicine Frontier Program, Division of Human Genetics, Department of Pediatrics, The Children’s Hospital of Philadelphia, ²Department of Pediatrics, University of Pennsylvania Perelman School of Medicine

Summary

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C Elegans

Mitochondrial Disease

Locomotor Activity

Semi automated Assays

Drug Screening

Motility Assays

Neuromuscular System

Experimental Conditions

Detection Sensitivity

Worm Behavior

Synchronization Techniques

Chapters in this video

0:04

Introduction

0:47

Worm Locomotor Activity Analysis in Liquid Medium on Glass Slides

1:37

C. elegans Locomotor Activity Recording Analysis in ZebraLab Software

3:30

Worm Locomotor Activity Analysis in Liquid Medium in 96-Well Plate Format

4:30

Results: Comparative Analysis of Locomotor Activity by ZebraLab and WormScan Software Assays

5:14

Conclusion

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