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Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

DOI :

10.3791/62548-v

April 21st, 2021

April 21st, 2021

2,913 Views

1Department of Chemical and Biomolecular Engineering, Clemson University, 2Department of Biological Sciences, Clemson University, 3Department of Bioengineering, Clemson University

Polymersomes are self-assembled polymeric vesicles that are formed in spherical shapes to minimize Gibb's Free Energy. In the case of drug delivery, more elongated structures are beneficial. This protocol establishes methods to create more rod-like polymersomes, with elongated aspect ratios, using salt to induce osmotic pressure and reduce internal vesicle volumes.

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