Spherical Polymersome Formation Using a Solvent Injection Method
2:24
Dialysis to Remove Organic Solvent
3:05
Dialysis Against Salt Gradients and Shape Modulated Polymersome Characterization
3:50
Results: Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
5:36
Conclusion
Transcription
Nanoparticle shape influences cellular uptake, but limited work has been done to change the shape of polymersomes. This protocol demonstrates how to elongate polymersomes for enhanced drug delivery applications. This technique provides a simple ap
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Polymersomes are self-assembled polymeric vesicles that are formed in spherical shapes to minimize Gibb's Free Energy. In the case of drug delivery, more elongated structures are beneficial. This protocol establishes methods to create more rod-like polymersomes, with elongated aspect ratios, using salt to induce osmotic pressure and reduce internal vesicle volumes.