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A Minimally Invasive, Fast Spinal Cord Lateral Hemisection Technique for Modeling Open Spinal Cord Injuries in Rats

DOI :

10.3791/63534-v

March 23rd, 2022

March 23rd, 2022

1,558 Views

1Department of Conservative Dentistry, Faculty of Dentistry, Semmelweis University, 2Department of Oral Biology, Faculty of Dentistry, Semmelweis University, 3Centre for Translational Medicine, Semmelweis University, 4Department of Molecular Biology, Faculty of Medicine, Semmelweis University, 5Institute of Translational Medicine, Faculty of Medicine, Semmelweis University, 6Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University

Here, we describe a new, fast technique modeling open spinal cord injury in rats that eliminates laminectomy. Lateral hemisection is performed while viewing through a microscope. The technique is versatile and can also be used in the cervical, thoracic, and lumbar regions of the spinal cord of other animals.

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